急性缺血性卒中患者阿司匹林抵抗与血小板补体C4d的相关性研究  

Platelet Complement C4d and Aspirin Resistance in Patients with Acute Ischemic Stroke

作　　者：但毕堂[1] 许康[1] 张晓琴[2] 强文 

机构地区：[1]湖北省新华医院神经内科,武汉430015 [2]武汉大学中南医院神经内科,武汉430077 [3]武汉市血液中心,武汉430061

出　　处：《神经损伤与功能重建》2009年第4期257-259,共3页Neural Injury and Functional Reconstruction

摘　　要：目的:探讨急性缺血性卒中(AIS)患者血小板补体C4d与阿司匹林抵抗(AR)的关系。方法:120例AIS患者服用阿司匹林(100mg/d)2周后测定血小板聚集率(PAG)。根据PAG将AIS患者分为AR组和阿司匹林敏感组(AS组),采用流式细胞术检测2组C4d阳性表达率。结果:120例AIS患者中16例(13%)存在AR(AR组),其余104例归入AS组,AR组C4d阳性表达率明显高于AS组(75.0%,3.85%,P<0.001)。结论:血小板补体C4d可作为AIS患者阿司匹林治疗中早期识别AR的指标之一。Objective ：To investigate the changes of platelet complement C4d in aspirin-treated patients with acute ischemic stroke （AIS）, and to explore the relationship between the expression of platelet complement C4d and aspirin resistance in acute ischemic stroke patients. Methods： All the 120 acute ischemic stroke patients had received aspirin therapy （aspirin 100 rag/d, two weeks）. The Platelet aggregation （PAG） induced by adenosine diphosphate （ADP） and arachiodonic acid （AA） were detected. According to PAG, AIS group was divided into aspirin-resistant and aspirin-sensitive subgroups. C4d positive platelets were detected by FCM. Results： Aspirin resistance was found in 16 （13~//00） patients, and 104 （87~） patients were aspirin-sensitive. When compared to the aspirin-sensitive subgroup, the expression of pIatelet C4d in the aspirin resistant subgroup was significantly higher. Conclusion： Platelet complement C4d may be used as a maker to evaluate AR in AIS patients treated with aspirin.

关 键 词：血小板补体C4d 急性缺血性卒中 阿司匹林抵抗 

分 类 号：R741[医药卫生—神经病学与精神病学] R743[医药卫生—临床医学]