结肠癌患者Wnt信号通路的变化和作用  

The changes and and roles of Wnt signaling pathway in colon cancer patients

作　　者：陈伙辉 汪森明[2] 陈燕武[1] 陈广幸[1] 吴凤坚 张健[2] 

机构地区：[1]广东省肇庆市第二人民医院肿瘤科,526060 [2]南方医科大学珠江医院肿瘤科

出　　处：《中国实用医药》2009年第7期11-12,共2页China Practical Medicine

摘　　要：目的探讨结肠癌患者Wnt信号通路的变化情况及其作用意义。方法利用Human Ge-nome U133Plus2.0基因芯片对结肠正常黏膜组织和癌组织基因表达谱进行检测,分析Wnt信号通路基因表达变化情况。结果Wnt信号通路中FRP、Frizzled、CK2、p53、PP2A、CKIα、JNK、CaMKII、CaN、c-jun、cyc-D等关键基因均呈下调,调控着细胞周期、基因转录等。结论Wnt信号通路可能是调控结肠癌演变过程的重要信号通路之一。Objective To study the changes and roles of Wnt signaling pathway in colon cancer patients. Methods The Human Genome U133 Plus 2. 0 Array were used to analyze gene expression profiles in colon cancer and normal tissues. The genes related to Wnt signaling pathway were selected through genechip data analyasis. Results The key genes related to Wnt signaling pathway of FRP, Frizzled, CK2, p53, PP2A, CKIα, JNK, CaMKII, CaN, c-jun, cyc-D were down regulation, which controled the cell cycle and gene transcription of the vascular endothelial cell. Conclusion Wnt signaling pathway may be one of the most important pathway to control the development of colon cancer.

关 键 词：结肠癌 WNT信号通路 基因芯片 

分 类 号：R735.35[医药卫生—肿瘤]