KMG微球与碘油在选择性支气管动脉栓塞治疗中晚期肺癌的疗效分析  

Effects of KMG microballoons and lipiodol on selective bronchial arterial embolism in advanced lung cancer

作　　者：蒙志斌[1] 马亦龙[1] 康平[1] 李志坤[1] 欧盛秋[1] 

机构地区：[1]广西医科大学附属肿瘤医院介入治疗科,南宁市530021

出　　处：《广西医学》2009年第7期930-933,共4页Guangxi Medical Journal

基　　金：广西科学基金(桂科自0640162)

摘　　要：目的探讨选择性支气管动脉灌注海藻酸钠微球血管栓塞剂（KMG）微球栓塞化疗与碘油栓塞化疗治疗非小细胞肺癌的临床效果。方法70例中晚期非小细胞肺癌患者单盲法随机分为两组,每组35例。两组患者都采用经支气管动脉灌注吉西他滨、顺铂方案治疗（吉西他滨1.0-1.4 g/m^2,顺铂60-80 mg/m^2）,接着A组在选择性支气管动脉灌注化疗药后用KMG微球栓塞,B组选择性支气管动脉灌注碘油栓塞。结果近期缓解率A组74.0%、B组48.0%,两组比较差异有统计学意义（P=0.048）;中位生存期A组18个月、B组11个月;生存1年以上患者A组占65.0%、B组占40.0%,A组1年生存率优于B组（P=0.031）。结论经超选择性支气管动脉内灌注KMG微球栓塞化疗是治疗中晚期肺癌最有效的方法之一,其疗效明显优于支气管动脉灌注碘油栓塞化疗。Objective To explore clinical effects of selective bronchial arterial embolism with KMG microballoons and lipiodol on patients with non-small cell lung cancer, Methods Seventy patients with advanced non-small cell lung cancer were divided into selective bronchial arterial embolism with KMG microballoons group （ B, n = 35 ） and with lipiodol group （ A, n = 35 ） by mean of single-blind method. The patients of the two groups were all given intra-bronchial arterial infusion chemotherapy of GEMZAR and DDP （dosage： GEMZAR 1.0 - 1.4 g/m^2 and DDP 60 - 80 mg/m^2 ）, then group B embelized with lipiodol and group A embolized with KMG microballoons. Results Intbe group A,the remission rate was 74.00% ,and in the group B was 51.00%. There was a significant difference between the two groups （P =0. 048）. The median survival period of group A was 18 months,while B group was 11 months. The survival rate （mere than one year） was 65.00% in group A and 40. 00% in group B. There was a significant difference between the two groups （ P = 0. 031 ）. Conclusion Selective bronchial arterial embolism with KMG microballoons is one of the best methods in therapy for the advanced lung cancer;the clinical curative effect is better than selective bronchial arterial embolism with lipiodol alone.

关 键 词：肺癌 选择性支气管动脉栓塞 KMG微球 碘油 

分 类 号：R734.2[医药卫生—肿瘤]