后程加速超分割放射治疗Ⅲ期非小细胞肺癌的疗效分析  

Analysis of Late-course Accelerated Hyperfractionation Radiotherapy in the Treatment of Stage Ⅲ Non-small Cell Lung Cancer

作　　者：潘辉林[1] 黄岩[1] 宋慧胜[1] 冯正富[1] 汤锐明[1] 何耀武[1] 

机构地区：[1]暨南大学第五附属医院,广东省清远市人民医院肿瘤防治中心,清远市511500

出　　处：《广西医学》2009年第7期933-936,共4页Guangxi Medical Journal

基　　金：广东省清远市科技计划项目(清科2005-14)

摘　　要：目的观察后程加速超分割放射治疗Ⅲ期非小细胞肺癌的疗效。方法110例Ⅲ期非小细胞肺癌患者入院先后顺序随机分为两组,其中常规组55例采用常规分割放射治疗,总剂量DT 66 Gy,分33次,共6.6周。后超组55例组采用后程加速超分割放射治疗,先常规分割放疗至DT 40 Gy,分20次,共4周;后改加速超分割放射治疗:1.5 Gy/次,2次/d,间隔≥6 h,总剂量DT 70 Gy,分40次,共6周。结果近期疗效:后超组优于常规组(P<0.05);远期疗效:后超组1、2、3年总生存率分别为76.4%、65.5%、47.3%,常规组分别为50.9%、30.9%、18.2%,两组比较差异有统计学意义(P<0.05);后超组1、2、3年局控率分别为72.7%、56.4%、45.5%,常规组分别为47.3%、32.7%、18.2%,两组比较差异有统计学意义(P<0.05);两组急性放射性食管炎、气管炎和肺炎发生率差异无统计学意义(P>0.05)。结论采用后程加速超分割放射治疗能提高Ⅲ期非小细胞肺癌的放射治疗疗效,急性放射反应与常规分割放射治疗相似,且患者能耐受,其远期疗效有待进一步观察。Objective To investigate the late-course accelerated hyperfractionation （LCAH） radiotherapy for stage Ⅲ non-small cell lung cancer. Methods 110 cases of stage Ⅲ non-small cell lung cancer patients were randomly divided into 2 groups,55 cases in conventional group were given conventional radiation therapy：total dose DT 66 Gy ,33 times, a total 6.6 weeks. 55 cases in LACH group were given LCAH therapy： DT 40 Gy, 20 times, a total of 4 weeks, followed by hyperfractionated accelerated radiation therapy： 1.5 Gy/ times,2 times/d,interval ≥ 6 h, the total dose DT 70 Gy, sub-40 times, a total of 6 weeks. Results LCAIt group was better than the conventional group in term of short-term effect （ P 〈 0.05 ） ;long-term effect ： the 1 - ,2 - and 3 -year of total survival rate of LCAH group were 76.4% ,65.5% and 47.3%, respectively, while the conventional group were 50. 9%, 30.9% and 18.2%, respectively, there was significant difference between the two groups （P 〈 0.05 ） ; the 1,2 and 3 year of total local control rate of LCAH group were 72. 7%, 56.4% and 45.5% ,respectively,in conventional group were 47.3% ,32.7% and 18.2 %, respectively,there was statistical difference between the two groups （P 〈0.05） ;no significant difference was found in regard to acute radiation esophagitis,bronehitis and pneumonia between two groups （P 〉 0.05）. Conclusion The LACH therapy can improve effects of radiation therapy on the stage m non-small cell lung cancer, acute radiation reaction is similar to conventional radiation therapy, and patients can be tolerated, but its lung-term effect has yet to be seen.

关 键 词：肺肿瘤 非小细胞肺癌 放射治疗 后程加速超分割放疗 

分 类 号：R734.2[医药卫生—肿瘤]