性别对海洛因相关环境线索诱发心理生理反应的影响  

The impact of gender on the psycho-physiological reactions to heroin-related cues in abstinent heroin dependent patients.

作　　者：范成路[1] 赵敏[1] 杜江[1] 曾庆枝 陈晗晖[1] 孙海明[1] 袁颖[1] 陈莉敏 

机构地区：[1]上海交通大学医学院附属精神卫生中心,上海200030

出　　处：《中国神经精神疾病杂志》2009年第7期413-416,共4页Chinese Journal of Nervous and Mental Diseases

基　　金：上海市卫生局科研基金项目(编号:054129);上海市申康医院发展中心适宜技术联合开发推广应用项目(编号:SHDC12007223);上海市禁毒基金项目(编号:0601)

摘　　要：目的了解康复期海洛因依赖者对吸毒相关环境线索的心理生理反应的性别差异。方法采用自身配对设计,173例男性和235例女性康复期海洛因依赖者观看吸毒相关视频的同时给予海洛因模拟物及吸毒用具刺激,用生物反馈仪记录诱发前、中、后的心理生理反应。结果环境线索诱发使男女海洛因依赖者的皮温随时间变化而不同,其中诱发中与诱发后阶段比较差异有统计学意义(P<0.05);环境线索诱发导致女性诱发中阶段的呼吸频率和诱发后阶段的皮温均低于男性(P<0.01)。结论环境线索诱发对男女性的呼吸频率和皮温指标反应具有不同影响,且性别对皮温的影响随时间阶段的变化而不同。Objective To understand gender differences of psycho-physiological responses to heroin related cues in abstinent heroin dependent patients. Methods In the self-controlled study, 173 male and 235 female abstinent heroin addicts were exposed to videotapes of heroin using and simulacrum after the self relaxation. The psycho-physiological reactions were measured by Multi-Biofeedback instrument before, during and after cue exposures. Results Using covariance analysis of repeated measures, we found that gender had different impact on the change trends in skin temperature （ST） between ＂during＂ and ＂after＂ cue exposures （ P 〈 0. 05 ）. Female heroin dependent patients had lower respiration rate （RT） than male in the ＂during＂ stage, and had lower ST in ＂after＂ stage（P 〈 0. 01 ）. Conclusions Gender was responsible for the differences in RT and ST when heroin-related cues exposed, and the impact of gender on Skin Temperature （ST） change along with time.

关 键 词：海洛因依赖 环境刺激 心理生理反应 性别差异 

分 类 号：R749.6[医药卫生—神经病学与精神病学]