玻璃体腔注射曲安奈德与联合黄斑格栅样激光光凝治疗黄斑水肿疗效的比较  

Intravitreal triamcinolone injection combined with or without macular grid laser photocoagulation to treat macular edema

作　　者：段雅剑[1] 贾亚丁[1] 张棉花[1] 

机构地区：[1]山西省眼科医院视网膜病科,太原030002

出　　处：《中华眼底病杂志》2009年第4期270-274,共5页Chinese Journal of Ocular Fundus Diseases

摘　　要：目的比较单纯玻璃体腔注射曲安奈德（IVTA）与IVTA联合黄斑格栅样激光光凝（MLG）治疗黄斑水肿的疗效。方法经眼底检查及光相干断层扫描（0CT）检查确诊的黄斑水肿患者89例109只眼，视力手动～0．8，平均视力0．19±0．13；眼压7～21mmHg（1mmHg一0．133kPa），平均眼压13．78mmHg。所有患者行OCT及微视野检查，黄斑中心凹厚度为（570±182）μ°；黄斑中心凹4。范围内视网膜平均光敏感度为（5．07±3．94）dB，固视点百分比为70．67％。所有患眼均接受IVTA治疗，其中39例48只眼在IVTA后1个月行MLG，为IVTA联合MI。G组；其余50例61只眼未行MLG，为单纯IVTA组。对比分析患者治疗前以及治疗后1、3、6、12个月最佳矫正视力（BcVA）、眼压，晶状体及跟底检查以及OCT、微视野检查结果，以手术后第12个月的观察指标作为疗效判定标准。对各组各项指标进行统计学分析。结果手术后12个月，IVTA联合MI。G组与单纯IVTA组BCVA分别为0．41±0．20、0．24±0．19，二者比较差异有统计学意义（t=4．503，P〈0．05）；两组黄斑中心凹厚度分别为（309±187）、（487±206）μm，二者比较差异有统计学意义（t=4．717，P〈0．05）；两组黄斑中心凹4°平均光敏感度分别为（8．24±4．64）、（6．30±3．22）dB，二者比较差异有统计学意义（t=2．467，P〈0．05）；两组固视点百分比分别为（87．01±19．70）、（78．85±20．41）％，二者比较差异有统计学意义（t=2．110，P〈0．05）。随访期间单纯IVTA组黄斑水肿复发28只眼，IVTA联合MLG组8只眼复发。结论IVTA联合MLG较单纯IVTA治疗黄斑水肿更为有效。Objective To compare the efficacy of intravitreal triamcinolone （IVTA） injection and IVTA combined with macular laser grid photocoagulation （MLGP）to treat macular edema. Methods Consecutive 89 patients （109 eyes）diagnosed with macular edema by examinations of ocular fundus and optical coherence tomography （OCT）. The visual acuity was hand moving- 0. 8 （0.19± 0. 13）; the intraocular pressure（IOP）ranged from 7 mm Hg to 21 mm Hg（1 mm Hg=0. 133 kPa）and the average IOP was 13.78 mm Hg. All the patients received OCT and microperimetry examinations, the central macular thickness was （570 ± 182） μm;the average light sensitivity was （5.07 ±3.94） dB and the fixation percentage was 70.67% within 4 ° area around the macular fovea. All the patients received IVTA treatment,39 patients （48 eyes）further received MLGP 1 month later （IVTA-MLGP group）. The remaining 50 patients （61 eyes） without MLGP treatment was the IVTA group. Best corrected visual acuity （BCVA）, IOP, lens, OCT and microprimetry examinations before and after IVTA （1, 3, 6, 12 months） were followed and analyzed. Results On the 12th months, the BCVA in IVTA-MLGP and IVTA group was （0.41± 0.20）, （0.24 0.19） respectively （P〈0. 05）; the central macular thickness was （309± 187） and （487± 206） μm respectively（P〈0.05） ;the mean light sensitivity of 4° central macular was （8.24±4.64）and（6.30±3.22） dB respectively （P〈 0.05）; the fixation percentage was （87.01± 19.70）% and （78.85 ± 20.41） respectively （P〈0.05）. During the follow up recurrent macular edema was noticed in 28 eyes of IVTA group and 8 eyes of IVTA-MLGP group. Conclusions IVTA combined with MLG was more effective than IVTA to cure macular edema.

关 键 词：黄斑水肿 囊样/治疗 曲安奈德/治疗应用 激光凝固术/方法 治疗效果 

分 类 号：R779.63[医药卫生—眼科] R774.5[医药卫生—临床医学]