西酞普兰与帕罗西汀治疗脑卒中后抑郁症的对照研究  

作　　者：宋学云[1] 刘素萍[1] 苗冬云[1] 

机构地区：[1]河南省焦作市人民医院神经内科,河南焦作454002

出　　处：《中外医疗》2009年第21期2-3,5,共3页China & Foreign Medical Treatment

摘　　要：目的评价西酞普兰和帕罗西汀治疗脑卒中后抑郁症(PSD)的临床疗效和安全性。方法将56例脑卒中后抑郁症患者采用随机方法分成两组,分别给予西酞普兰与帕罗西汀治疗6周,采用汉密顿抑郁量表(HAMD)和副反应量表(TESS)对治疗前后的情况进行比较分析。结果西酞普兰组显效率78.57%,帕罗西汀组显效率75.0%,2组间相比差异无统计学意义(P>0.05);治疗前后相比,西酞普兰及帕罗西汀组HAMD总分均有显著下降(P<0.01),差异有统计学意义;不良反应发生率西酞普兰组42.9%,帕罗西汀组46.4%,两组比较无统计学意义(P>0.05)。结论西酞普兰和帕罗西汀治疗脑卒中后抑郁症均安全有效。Objective To study the efficacy and safety of cltalopram and paroxetine in the treatment of post--stroke depression Methods 56 patients with post-stroke depressiou were divided into two groups with citaloprem or paroxetine for 6 weeks respectively. The therapeutic responses were evaluated with HAMD and TF_.SS. Results Excellence rates were respectively 78.57% in oitaloprarn and 75% in the paroxetine group, which showed no significant difference （P〈0.05）, The scores of HAMD decreased more markedly after the treatment than before the treatment in two groups（P〈0.01）s incidences of adverse effects were respectively 42.9% in the citalopram arm and 42.9%, in the paroxetine group,difference was not significant（P〈0.05）,Conclusion In the treatment of post- stroke depression,citalopram and paroxitine all have good curative effects, and have light side effects.

关 键 词：西酞普兰 帕罗西汀 脑卒中后抑郁症 

分 类 号：R742[医药卫生—神经病学与精神病学]