正交设计优选调胃颗粒挥发油的提取工艺  

The optimization of the extraction process for volatile oil of Tiaowei Granules by orthogonal design

作　　者：孙文格 郑倩[1] 张桂侠[1] 

机构地区：[1]石家庄市中医院,河北石家庄050051

出　　处：《中国医药导报》2009年第22期78-79,共2页China Medical Herald

基　　金：河北省中医药管理局课题(2007182)

摘　　要：目的:研究调胃颗粒挥发油的提取方法。方法:采用正交设计L9(34)方法,从药材粉碎度(A)、加水量(B)及提油时间(C)三个方面考察挥发油得量,筛选提取条件。结果:最佳提油方案为A1B2C2,即白术、木香直径小于1cm、加水量8倍、提油时间6h;影响因素强弱依次为A>B>C,其中,饮片规格(药材粉碎度)对挥发油收率的影响有统计学意义(P<0.05)。结论:采取正交设计研究挥发油提取方法简单合理、工艺可行。Objective： To study on the extraction process for volatile oil of Tiaowei Granules. Methods： By orthogonal design L9（3^4） method, the degree of grinding for medicinal herbs（A）, water consumption（B）, reflux time（C） were all used as indication to optimize the extraction process for volatile oil. Results： The best condition of extraction for volatile oil was A1B2C2, namely the diameter of medicinal herbs was smaller than 1 cm pieces for Rhizoma Atractylodis Macrocephalae and Radix A ucklandiae, the proportion of solid：liquid was 1：8, and the reflux time is 6 hours. The impact sequence was A〉B〉 C, and the diameter of medicinal herbs had the most important influence on the extraction process for volatile oil （P〈0.05）. Conclusion： The technology of the extraction process for volatile oil is simple, reasonable and practical by orthogonal intersection analysis.

关 键 词：调胃颗粒 挥发油 中药制药工艺 正交设计 提取工艺 

分 类 号：R284.2[医药卫生—中药学]