胎儿颈部软组织厚度及母体血清标记物筛查胎儿异常效果  

Correlaltion of fetal nuchal translucency thickness with maternal serum markers in screening fetal dysplasia

作　　者：侯红瑛[1] 郝秀兰[1] 王林琳[1] 滕奔琦[1] 霍道贵[1] 范建辉[1] 

机构地区：[1]中山大学附属第三医院产科,广东广州510630

出　　处：《中国热带医学》2009年第8期1434-1436,共3页China Tropical Medicine

基　　金：广东省科技厅项目(2008B030301123)

摘　　要：目的探讨胎儿颈部软组织厚度和母体血清标记物在筛查胎儿发育异常的价值。方法收集399例孕11～14周超声测定胎儿颈部软组织（nuchal translucency，NT）厚度和1125例孕14-21周测定母体二联血清标记物（AFP＋Free—B—HCG），并对其胎儿结局进行追踪。结果胎儿NT测定和母体血清标记物用于筛查胎儿发育异常的敏感度分别为50．00％和51．11％，特异度分别为98．69％和74．44％。胎儿NT筛查胎儿发育异常的截断值初步计算为2．25mm。结论胎儿NT和母体血清标记（AFP＋Free—β—HcG）筛查胎儿发育异常具有较高的敏感性。Objective To explore the value of fetal nuchal translucency （NT） thickness and maternal serum markers in screening fetal dysplasia. Methods There 399 NT thickness data and 1 125 second trimester maternal AFP＋Free-β-HCG were collected and analyzed. Results The sensitivities of fetal NT thickness and maternal serum marker in screening fetal dysplasia were 50.00% and 51.11% ,separately,while the specilicities were 98.69% and 74.44%. The cut-off value of fetal NT thickness in screening fetal dysplasia was 2.25mm. Conclusion Fetal NT thickness and matemal scrum makers could be used in predicting fetal dysplasia.

关 键 词：胎儿颈部软组织厚度 甲胎蛋白 绒毛膜促性腺激素 发育异常 血清标记物 产前筛查 

分 类 号：R714.1[医药卫生—妇产科学]