异甘草酸镁联合还原型谷胱甘肽治疗DILI疗效观察  

Observation on the effects of magnesium isoglycyrrhizinate combined with reduced glutathione on drug-induced liver injury

作　　者：徐强胜[1] 杨澍[1] 王洪[1] 饶宗华[1] 田建华[1] 曾秀忠 黄哲梅 

机构地区：[1]深圳市宝安区人民医院感染内科,广东深圳518101

出　　处：《中国热带医学》2009年第8期1548-1549,共2页China Tropical Medicine

摘　　要：目的观察异甘草酸镁联合还原型谷胱甘肽治疗药物性肝损伤的临床疗效。方法选择我科2005年5月～2008年10月因药物性肝损伤住院患者84例,随机分为两组,每组42例。对照组:给予甘草酸二铵等治疗;治疗组:给予异甘草酸镁联合还原型谷胱甘肽治疗,疗程4周后将两组治疗效果进行比较。结果治疗组在临床症状改善及肝功能恢复方面优于对照组,两组存在显著性差异。结论异甘草酸镁联合还原型谷胱甘肽治疗药物性肝损伤疗效较好。Objective To observe the effects of magnesium isoglycyrrhizinate combined with reduced glutathione on drug-induced liver injury. Methods There 84 patients with drug-induced liver injury were randomly divided into group A treated with diammonium glycyrrhizinate and group B treated with magnesium isoglyeyrrhizinate combined reduced glutathione. The results in the two groups were compared four weeks after treatment. Results The effective rate in group A was 90.48% （38/42） and that in the group B wasT1.43% （30/42）,showing significant difference （x^2=7.16,P〈0.05）. Conclusion Magnesium isoglycyrrhizinate combined with reduced glutathione is effective for treatment of drug-induced liver injury.

关 键 词：异甘草酸镁 还原型谷胱甘肽 药物性肝损伤 疗效 

分 类 号：R575.1[医药卫生—消化系统]