257例Ⅱa期直肠癌根治术后不同治疗方法的疗效比较  

Comparison Among Different Treatments in 257 Cases of Stage Ⅱ a Rectal Cancer

作　　者：刘振洋[1] 胡英[2] 周慧俊[1] 曾毅栋[1] 沈华[1] 殷先利[1] 

机构地区：[1]湖南省肿瘤医院内科,湖南长沙410013 [2]湖南省肿瘤医院放疗科,湖南长沙410013

出　　处：《医学临床研究》2009年第7期1238-1240,共3页Journal of Clinical Research

摘　　要：【目的】分析比较Ⅱa期直肠癌不同治疗方法的临床疗效。【方法】257例患者全部行直肠癌根治术。单纯手术78例；术后行化疗66例，采用5-Fu／LF、DDP＋5-Fu／LF或L-OHP＋5-Fu／LF方案、化疗2周期以上；术后放疗54例，照射剂量45～50Gy／5～5．5周；术后放化疗59例，术后放疗在化疗2周期后进行。【结果】各组1、3、5年生存率及远处转移率均无明显差别（P〉0．05），但术后放疗组与术后放化疗组的局部复发率下降（P〈0．05）。各组治疗不良反应均可耐受。【结论】Ⅱa期直肠癌术后放疗及术后放化疗能降低局部复发率，但对患者生存率无明显影响。[Objective] To compare the clinical efficacy of different treatments in stage Ⅱa rectal cancer. [Methods] All 257 patients undergoing radical resection of rectal carcinoma were divided into four groups according to therapy. Seventy eight patients underwent operation alone, and 66 cases received postoperative 5-Fu-based chemotherapy, and 54 cases received postoperative radiotherapy with 45-50Gy/5-5.5 weeks, and 59 cases received postoperative chemoradiotherapy. The radiotherapy was used after two cycles of chemotherapy. [Results] There was no significant difference in the 1-, 3-, 5-year metastatic rates and overall survival rates among these four groups, but the postoperative radiotherapy or chemoradiotherapy decreased local recurrence rate. The side effects of four groups were tolerable. [Conclusion]The postoperative radiotherapy or chemoradiotherapy can improve local recurrence rate of stage Ⅱa rectal cancer, but has no significant effect on survival rate.

关 键 词：直肠肿瘤/治疗 

分 类 号：R735.37[医药卫生—肿瘤]