信号转导与转录活化因子3与恶性肿瘤侵袭转移关系的研究  

Progress in relationship between Stat3 and invasion and metastasis in cancer

作　　者：张倩倩(综述)[1] 王凤云(综述)[1] 张艳桥(审校)[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院内八科,150040

出　　处：《国际肿瘤学杂志》2009年第7期486-488,共3页Journal of International Oncology

摘　　要：信号转导与转录活化因子3（Stat3）作用于细胞核内特异的DNA片断，调控着多种与细胞增殖凋亡相关的功能蛋白的表达。作为肿瘤信号转导通路的交汇点之一，它可由多条途径激活，不仅具有强烈的抑制细胞凋亡、促进细胞增殖的作用，还参与了恶性肿瘤的血管生成，侵袭转移以及免疫逃逸过程。因阻断该途径可能成为切断侵袭转移的一个潜在的新靶点，目前有关该因子阻断剂的研究成为热点。Signal transdcuers and activators of transcription3 （ Stat3 ） is activated by a wide range of eytokines and growth factors following binding to special DNA domain and affects the expression of a variety of genes in modulating the process of cell proliferation, differentiation, and apoptosis. As a point of convergence for many oneogenic tyrosine kinase signaling pathways, it can be activited by sevral accesses. Stat3 is not only involved in the function of both apoptosis suppression,proliferation promotion, but also participates the process of angiogenesis, invasion and immune evasion. For repression of this way maybe a new target for break of cancer invasion and metastasis, blockers of Star3 has become the focus of many researches.

关 键 词：DNA结合蛋白质类 肿瘤转移 

分 类 号：R36[医药卫生—病理学] R735.2[医药卫生—基础医学]