基质金属蛋白酶2与直肠癌关系的研究  

The correlation between of matrixmetal-loproteinase2 and reactal cancer

作　　者：鹿国俊[1] 曹学成[2] 吕芳丽[3] 

机构地区：[1]山东省安丘市人民医院肿瘤外科,262100 [2]安丘市人民医院神经外科 [3]安丘市人民医院神经内科

出　　处：《国际肿瘤学杂志》2009年第7期554-557,共4页Journal of International Oncology

摘　　要：目的研究直肠癌中基质金属蛋白酶2（MMP2）及其组织抑制物2（TIMP2）的表达与直肠癌细胞分级、临床病理分期的关系及其在评估患者预后中的意义。方法免疫组化法检测直肠癌原发灶MMP2、TIMP2表达水平，x^2检验进行统计学分析，应用Kaplan-Meier法进行单因素生存分析（Logrank检验）。结果直肠癌组织中MMP2及TIMP2表达显著高于正常直肠组织。随恶性程度升高，MMP2表达呈增加趋势，而TIMP2表达呈下降趋势。直肠癌中MMP2与TIMP2呈负相关。结论直肠癌组织中MMP2与TIMP2的表达与直肠癌的细胞分级、临床病理分期和预后有关，MMP2表达水平及MMP2与TIMP2的失衡在直肠癌的侵袭发挥重要作用。MMP2表达水平及MMP2与TIMP2的平衡状况可作为评估直肠癌预后的指标，并能为探寻新的治疗方法提供线索和依据。Objective Studing the relationship among matrixmetal-loproteinase2 （MMP2）, the tissue inhibitors of metalloprotein-ase2 （TIMP2） and clinicopathological characteristics such as histological grade, clinicopathological stage of the rectal cancer. Assessing the significance of MMP2 and TIMP2 expression in rectal cancer for prognosis and treatment. Methods To test the expression level of MMP2 and TIMP2 in rectal cancer patients with immunohistocbemisty method. Results were analysised with X2 test. The Kaplan-Meier （Log-rank test） was used for univariate survival analysis. Results The positive rates of MMP2 and TIMP2 expression in rectal canee are higher in comparison with normal tissues. With MMP2 have a trendence of increasing the positive expression of TIMP2 decreases. Conclusion MMP2 and TIMP2 relate obviously with the clinicopathological character of the rectal cancer. They may play an important role in the proliferation, invasion and of the cancer. Testing the level of expression of MMP2 and TIMP2 may be helpful to prejudge the prognosis of the patients with rectal cancer. Some new therapic methods relating to MMP2 and TIMP2 may give patients with rectal cancer a more satisfying treatment.

关 键 词：直肠肿瘤 明胶酶A 免疫组织化学 

分 类 号：R735.37[医药卫生—肿瘤]