超高倍甜味剂N-[3-(3-羟基-4-甲氧基苯基)丙基]-阿斯巴甜的合成研究  

Synthesis of High Potency Sweetener N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-aspartyl-L-henylalaninel-methylester

作　　者：吴美红[1] 郑建仙[1] 

机构地区：[1]华南理工大学轻工与食品学院

出　　处：《食品与发酵工业》2009年第6期1-5,共5页Food and Fermentation Industries

基　　金：国家自然科学基金资助项目(20576044)

摘　　要：开发安全,低成本,高甜度,性质稳定的甜味剂是食品工业的发展方向。文中从甜味机理出发,以3-羟基-4-甲氧基苯丙醛与阿斯巴甜为原料,通过钯碳催化,合成了N-[3-(3-羟基-4-甲氧基苯基)丙基]-阿斯巴甜。其中,由于疏水基团引入,甜度显著提高,约是蔗糖的23000倍,且合成工艺简单,产率高,为国内高倍甜味剂大型工业化提供了广阔前景。另外,文中还着重论述了重要中间体3-羟基-4-甲氧基苯丙醛制备,得率为49.8%,为开发新产品奠定了基础。The development of high potency sweetener changes rapidly, sweetener with safety, low cost, high degree of sweetness and top properties is the trend in food industry. On the basis of sweet mechanism, by the reaction of aspartame and 3-hydroxy-4-methoxyphenylpropylaldehyde under the catalysis Pd/C, a new sweetener N-[3-（3-hydroxy-4-methoxyphenyl） propyl]-aspartyl-L-henylalaninel-methylester is synthesized. Because of hydrophobic group added on aspartame derivative, the sweetness is 23 000 times higher than that of cane sugar. Furthermore, the method is simple and available with high yield. The paper summarizes the synthesis method of the important intermediate, 3- hydroxy-4-methoxyphenylpropylaldehyde, with 49. 8% yield, which makes the high potency sweetener possible.

关 键 词：3-羟基-4-甲氧基苯丙醛 N-[3-(3-羟基-4-甲氧基苯基)丙基]-阿斯巴甜 疏水基团 甜度 

分 类 号：TS264.9[轻工技术与工程—发酵工程]