能量多普勒检测膀胱癌血流相对灌注率及其与MVD、VEGF表达的相关性  

Intratumoral relative perfusion rate and the relation between MVD and expression of VEGF assessed with power Doppler imaging:in bladder carcinoma

作　　者：罗红缨[1] 李徽[2] 谢艳霞[2] 

机构地区：[1]湘南学院医学影像系超声诊断教研室,湖南郴州423000 [2]湘南学院附属医院病理科,湖南郴州423000

出　　处：《中国医学影像技术》2009年第7期1232-1234,共3页Chinese Journal of Medical Imaging Technology

基　　金：湖南省教育厅课题基金(08C821)

摘　　要：目的探讨能量多普勒(PDI)技术检测膀胱癌肿瘤内血流相对灌注率及其与微血管密度(MVD)、血管内皮细胞生长因子(VEGF)表达的关系。方法采用经直肠PDI技术检测45例膀胱癌患者肿瘤内血流信号,计算相对灌注率,术后采用免疫组化技术检测肿瘤MVD及VEGF表达。结果肿瘤内血流相对灌注率与MVD、VEGF阳性表达呈正相关。MVD、VEGF表达与膀胱癌的病理分级及浸润程度相关。VEGF表达阳性者MVD高于VEGF表达阴性者。结论能量多普勒超声联合上述免疫组化指标可从不同角度反映膀胱癌的血管生成特征,有助于对膀胱癌血管生成进行评价。Objective To evaiuate the relationship between relative perfusion rate assessed with power Doppler imaging （PDI） and microvessel density （MVD）, as well as expression of vascular endothelial growth factor （VEGF） in bladder carcinoma. Methods The transrectal ultrasound （TRUS） blood flow signal of bladder carcinoma was preoperatively detected with color Doppler imaging in 45 patients, and the relative perfusion rates were obtained for analysis. MVD and the expression of VEGF of excised tumor were assessed immunohistochemically. Results There were correlation between relative perfusion rate and MVD, the expression of VEGF. MVD and the expression of VEGF were related to pathologic grade and the invasiveness of tumor tissues. The expression of VEGF in bladder carcinoma was positively correlated to the tumor interstitial vascular density. Conclusion Combination of PDI and immunohistochemical parameters is useful for evaluating the angiogensis of bladder carcinoma from a different point of view.

关 键 词：膀胱肿瘤 超声检查 多普勒 血管内皮细胞生长因子 微血管密度 

分 类 号：R737.14[医药卫生—肿瘤] R445.1[医药卫生—临床医学]