非小细胞肺癌组织中RECK蛋白的表达及与预后的关系  

Expression of RECK in Non-Small Cell Lung Cancer Tissues and its Relationship with Prognosis

作　　者：张军[1] 张文君[1] 郭家龙[1] 

机构地区：[1]郧阳医学院附属太和医院胸心外科,442000

出　　处：《实用癌症杂志》2009年第2期135-137,共3页The Practical Journal of Cancer

基　　金：湖北省科技攻关项目(2004AA301C97)

摘　　要：目的探讨非小细胞肺癌组织中RECK的表达及其与预后的关系。方法采用免疫组化SP法检测RECK在48例肺癌组织和癌旁正常组织中的表达情况,通过Kaplan-Meier生存曲线法比较阳性组和阴性组患者的预后情况。结果肺癌组织中RECK表达阳性率为29.2%(14/48),在癌旁正常肺组织中阳性表达率为85.7%(42/48),两组比较差异有统计学意义(P<0.05)。RECK的表达与淋巴结转移和TNM分期有关,而与患者年龄、性别、肿瘤大小、组织学分化程度无关。与无淋巴结转移和Ⅰ、Ⅱ期的肺癌组织相比,在有淋巴结转移和Ⅲ期的肺癌组织中,RECK的阳性表达显著性降低(P<0.05)。RECK蛋白阴性组的患者的生存期较阳性组短,统计学上有显著性差异(P=0.018)。结论RECK蛋白在肺癌中具有低表达,在肺癌的侵袭和转移中发挥重要作用,并与肺癌患者的预后相关。Objective To study the expression and correlation of RECK and MT1-MMP in non-small cell lung cancer （ NSCLC ） and clinic pathological features. Methods Immunohistochemical SP method was used to detect the expression of RECK proteins in 48 NSCLC tissues and the same para-cancerous tissues. Kaplan-Meier and Log-rank test were used to compare the survival time of positive staining group and negative staining group. Results The positive rates of RECK in NSCLC carcinoma tissues were 29.2% （ 14/48 ） which is lower than that in para-cancerous tissues 85.7% （42/48） （ P 〈 0.05 ）. The positive rates of RECK was correlated with lymph node metastasis and TNM stage. There was no relationship with age, sex, pathology subtype and histological grades, respectively. The survival time in negative RECK staining group was significent shorter than that in RECK positive staining group. Conclusion RECK is lower-expressed in NSCLC and may play an important role in invasion and metastasis of NSCLC. Low-expression of RECK suggests poor prognosis in patient with NSCLC.

关 键 词：肺癌 回复引导半胱氨酸丰富蛋白含kazal基元 预后 

分 类 号：R734.2[医药卫生—肿瘤]