大肠癌组织中eIF4E和NF-κBp65表达及其临床意义  

The Expression and Clinical Significance of eIF4E and NF-κBp65 in Human Colorectal Cancer

作　　者：王宁菊[1] 袁春秀[1] 

机构地区：[1]宁夏医科大学附属医院肿瘤内科,750004

出　　处：《实用癌症杂志》2009年第2期144-147,共4页The Practical Journal of Cancer

摘　　要：目的探讨eIF4E和NF-κBp65在大肠癌发生发展过程中的作用。方法采用免疫组化方法,检测60例大肠癌及20例正常大肠组织中eIF4E和NF-κBp65的表达情况。结果eIF4E和NF-κBp65在大肠癌组织中阳性表达率分别为91.7%和65.0%,在正常大肠组织中分别为10.0%和20.0%。eIF4E表达与大肠癌患者性别、年龄、肿瘤病理分化程度、临床分期、淋巴结转移、根治术后复发转移率及生存率无关;与肿瘤浸润深度有关(P<0.05)。NF-κBp65表达与大肠癌患者性别、年龄无关;与肿瘤病理分化程度、临床分期、淋巴结转移、肿瘤浸润深度、根治术后复发转移率及生存率有关(P<0.05),且阳性表达者生存率低于阴性表达者。大肠癌组织中eIF4E表达与NF-κBp65表达呈正相关性。结论eIF4E表达与NF-κBp65表达在大肠癌的发生发展中起重要作用,其中NF-κBp65可作为判断大肠癌侵袭转移及预后的预测指标。Objective To investigate the significance of the expression of Eukaryotic Initiation Factor 4E （elF4E） and nuclear transcription factor-κBp65 （ NF-κBp65 ） in the carcinogenesis and development of colorectal cancer. Methods The expression of eIF4E and NF-κBp65 was detected in the tissues from 60 patients with colorectal cancer and 20 normal colorectal tissues by immunohistochemical assay. Results The positive expression rates of eIF4E and NF-κBp65 in the colorectal cancer tissues were 91.7% and 65.0% ;whereas the positive expression rates of eIF4E and NF-κBp65 in the normal colorectal tissues were 10.0% and 20.0%. The positive expression of eIF4E was associated with the tumor depth, but not correlated with the gender, age, histological differentiation, lymph node metastasis and Dukes＇ stage, postoperative recurrence and survival rate. The positive rates of NF-κBp65 were not correlated with the gender and age of the patients, but were associated with the histological differentiation,involvement depth ,lymph node metastasis, Dukes＇stage,postoperative recurrence and survival rate. The expression of eIF4E was positively correlated with the expression of NF-κBp65. Conclusion The high expression of eIF4E and NF-κBp65 may play an important role in the carcinogenesis of coloreetal cancer. NF-κBp65 might be a good marker of invasion, metastasis and prognosis of colorectal cancer.

关 键 词：大肠癌 eIF4E蛋白 NF-κBp65蛋白 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]