紫杉醇及蒽环类药物联合化疗治疗晚期乳腺癌的临床观察  

Comparative Study of the Combined Chemotherapy with Paclitaxel or Antracycline for Advanced Breast Cancer

作　　者：朱跃红[1] 罗以[1] 杨农[1] 吴尉[1] 林劲冠[1] 杨挚鹰[2] 

机构地区：[1]湖南省肿瘤医院,410013 [2]湖南师范大学医学院,410013

出　　处：《实用癌症杂志》2009年第2期158-161,共4页The Practical Journal of Cancer

基　　金：湖南省教育厅科学研究项目(07C568)

摘　　要：目的探讨紫杉醇联合蒽环类药物±CTX方案与CAF方案治疗晚期乳腺癌的近期临床疗效和不良反应。方法以紫杉醇联合蒽环类药物±CTX方案为观察组,CAF方案为对照组。结果观察组有效率为72.7%(16/22),对照组为53.8%(14/26),观察组优于对照组,但无显著性差异(P>0.05)。年龄,月经状况,ER、PR,基因表达,临床分期,远处转移等因素,对近期疗效无显著影响(P>0.05)。不良反应以白细胞减少为主,观察组Ⅲ-Ⅳ度发生率为59.1%,对照组为11.5%,两组比较有显著性差异(P<0.01),其他与化疗相关的不良反应程度均较轻,可耐受。结论对于晚期乳腺癌初用化疗者,CAF组与观察组相比疗效无显著差异且不良反应较轻,临床更具优势,值得临床广泛应用。Objective To study the short-term efficacy and toxicities of combined paclitaxel plus antracycline ± CTX and CAF treatment for advanced breast cancer. Methods Patients treated with paclitaxel plus antraeycline ± CTX were included in the study group, and patients treated with the CAF were included in the control group. Results The response rate was 72.7 % （16/22） for the study group, and 53.8% （14/26） for the control group, with no significant differences （ P 〉 0. 05 ）. Age, menstruation status, ER, PR, gene expression, clinical TNM stage and distant metastases had no significant correlations with the shortteim clinical efficacy （P 〉0.05）. The major toxicity was leucopenia,with 59.1% and 11.5% patients having III-1V leucopenia in the study and control group, respectively. This difference was statistically significant （ P 〈 0.01 ）. Other chemotherapy-related toxicities were mild and tolerable. Conclusion CAF chemotherapy has the same efficacy as the paclitaxel plus antracyeline ± CTX regime, but with less toxicities,in the treatment of patients with advanced breast cancer.

关 键 词：晚期乳腺癌 化疗 紫杉醇 蒽环类药 

分 类 号：R737.9[医药卫生—肿瘤]