p73在宫颈癌和宫颈上皮内瘤变中的表达  

Expression of p73 in Cervical Carcinoma and Cervical Intraepithelial Neoplasm

作　　者：庞天云[1] 郑小娟[2] 邓飞[2] 邹琳[1] 李飞虹[1] 胡新荣[2] 

机构地区：[1]广东医学院附属医院妇产科,524023 [2]广东医学院病理教研室,524001

出　　处：《实用癌症杂志》2009年第3期240-241,244,共3页The Practical Journal of Cancer

基　　金：2004湛江科技招标项目(编号:ZZ0405)

摘　　要：目的探讨p73在宫颈肿瘤的发生发展过程中的表达情况及其意义。方法采用免疫组织化学染色的方法对12例慢性宫颈炎、15例低度宫颈上皮内瘤变、25例高度宫颈上皮内瘤变和65例宫颈浸润癌进行检测,确定染色强度,计算阳性率并进行χ2检验分析。结果按照上述病变顺序,p73染色阳性率分别是75.0%、93.3%、68.0%、41.5%。宫颈炎及宫颈上皮内瘤变与宫颈癌相比,差异显著,P<0.005。但宫颈炎及宫颈上皮内瘤变间比较,无显著性差异。结论随着宫颈肿瘤发展程度的增加,p73的表达逐渐降低,进一步支持p73是宫颈肿瘤的抑癌基因。Objective Similar with p53,p73 is a potential tumor suppressor gene whose protein induces cell apoptosis. The purpose of this study was to observe the expression of p73 in the occurrence and development of cervical cancer and discuss the significance of the expression. Methods Immunohistochemistry was performed on 117 cases of cervical tissues including 12 cervicitis, 15 cases of low degree of cervical intraepithelial neoplasm,25 cases of high degree of cervical intraepithelial neoplasm and 65 cervical squamous cell carcinomas. The staining intensity and positive staining rate were determined and analyzed with statistics （χ^2 test）. Results The p73 positive staining rates were 75.0% ,93.3% ,68.0% and 41.5% in the cervicitis,low degree intraepithelial neoplasm, high degree of cervical intraepithelial neoplasm and cervical squamous cell carcinoma, respectively. The difference was significant according to the χ^2 test （P 〈 0. 005 ）. Conclusion As the development of cervical tumors was upgrading, the expression of p73 gradually decreased, which further supported that p73 may be a tumor suppressor gene of cervical cancer.

关 键 词：P73基因 宫颈癌 宫颈上皮内肿瘤 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]