神经节苷脂联合丹红注射液治疗脑梗死疗效观察  

Curative Effects of Ganglioside GM1 Combined with Danhong Injection for Acute Cerebral Infarction

作　　者：庄雷[1] 

机构地区：[1]安徽省蚌埠市第一人民医院神经内科,233000

出　　处：《中华全科医学》2009年第8期824-825,共2页Chinese Journal of General Practice

摘　　要：目的观察神经节苷脂(GM1)联合丹红注射液对急性脑梗死的治疗效果。方法急性脑梗死患者96例,将其随机分为联合治疗组48例,以神经节苷脂40mg+5%GS250ml静脉滴注,1次/d,共14d;合并丹红注射液20ml+5%GS250ml静脉滴注,1次/d,共14d。对照组48例,以丹红注射液20ml+5%GS250ml静脉滴注,1次/d,共14d。两组基础用药治疗相同。于治疗前、后对两组患者的神经功能缺损程度(NDS)及日常生活活动量(ADL)进行评分比较。结果治疗组在治疗前、后比较NDS评分及ADL评分差异有统计学意义(P<0.01);治疗组与对照组相比,NDS评分和ADL评分差异有统计学意义(P<0.05)。结论神经节苷脂(GM1)联合丹红注射液能更好地改善急性脑梗死患者的预后,降低患者的神经功能的缺损程度。Objective To observe the curative effects of ganglioside GM1 combined with Danhong injection in treatment of acute cerebral infarction（ACI）. Methods 96 eases with ACI were randomly divided into two groups. 30 eases in the combined treatment group were treated with GM1 40 mg and 5% GS 250 ml,iv gtt,qd for 14 days;as well as Danhong injection 20 ml and 5% GS 250 ml,iv gtt,qd for 14 days. 48 eases in the control group were treated with Danhong injection 20 ml and 5% GS 250 ml,iv gtt,qd for 14 days. The conventional treatments in two groups were same. The neural function deficient scale（NDS） and activity of daily living（ADL） scale were evaluated and compared before and after treatment between the two groups. Results In combined treatment group, there were significant differences in NDS and ADL between before and after the treatment（ P 〈 0.01 ）. The differences were obviously between NDS and ADL of the two groups （ P 〈 0.05 ）. Conclusion Ganglioside GM1 combined with Danhong injection can improve the prognosis of the patients with ACI preferably, also can lighten the neural function deficient.

关 键 词：神经节苷脂 丹红注射液 脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]