tPSA、f/tPSA在不同数值范围时tPSA、fPSA、f/tPSA与前列腺癌相关性研究  

Research on the Correlation between tPSA,fPSA,f/tPSA and Prostate Cancer in Different Range of tPSA,f/tPSA

作　　者：潘文海[1] 黄文胜[1] 李正明[1] 施国强[1] 过新民[1] 

机构地区：[1]广州市红十字会医院泌尿外科,广东广州510220

出　　处：《临床医学工程》2009年第8期26-28,共3页Clinical Medicine & Engineering

基　　金：2006年广东省社会发展领域科技计划项目(编号:63101)

摘　　要：目的研究tPSA、f/tPSA在不同数值范围时tPSA、fPSA、f/tPSA与前列腺癌的相关性。方法选择男性患者385人予血清tPSA、fPSA、f/tPSA测定,并行TRUS引导前列腺活检术或TURP术获得病理结果,对不同tPSA、f/tPSA范围内tPSA、fPSA、f/tPSA与前列腺癌作相关性分析。结果当tPSA≤4ng/ml时,tPSA、fPSA、f/tPSA均与PCa无显著相关性(P>0.05);当4<tPSA≤20ng/ml时,f/tPSA与PCa有显著相关性(P<0.05),而tPSA、fPSA均与PCa无显著相关性(P>0.05);当tPSA≥20ng/ml时,tPSA与PCa有显著相关性(P<0.05),而fPSA、f/tPSA则与PCa无显著相关性(P>0.05)。当f/tPSA<0.1时,tPSA与PCa有显著相关性(P<0.05),而fPSA、f/tPSA则与PCa无显著相关性(P>0.05);当f/tPSA≥0.1时,tPSA、fPSA均与PCa有显著相关性(P<0.05),而f/tPSA与PCa无显著相关性(P>0.05)。结论tPSA、f/tPSA在不同数值范围时tPSA、fPSA、f/tPSA与PCa的相关性是存在差异的,应根据不同tPSA、f/tPSA的范围选择相关性显著的指标进行分析。Objective To study the correlation between tPSA, fPSA, f/tPSA and prostate cancer in different range of tPSA, f/tPSA. Methods Levels of serums tPSA, fPSA, f/tPSA were measured in a total of 385 male patients. TRUS guided systematic prostate biopsy or TURP were performed and biopsy results were acquired to analyse the correlation between tPSA, fPSA, f/tPSA and prostate cancer in different range of tPSA,f/tPSA. Results TPSA, tPSA and f/tPSA had no correlation noticeably with PCa when tPSA was less than 4 ng/ml（P 〉 0.05）. When tPSA was within 4- 20 ng/ml, f/tPSA had correlation noticeably with PCa（P 〈 0.05）, but not for tPSA and fPSA（P 〉 0.05）. When tPSA was more than 20 ng/ml, tPSA had correlation noticeably with PCa（P 〈 0.05）, but not for tPSA and f/tPSA（P 〉 0.05）. When f/tPSA was less than 0.1, tPSA had correlation noticeably with PCa（P 〈 0.05）, but not for fPSA and f/tPSA（P 〉 0.05）. When f/tPSA was more than 0.1, tPSA and IPSA all had correlation noticeably with PCa（P 〈 0.05）, but not for f/tPSA（P 〉 0.05）. Conclusions It has different correlation between tPSA, fPSA, f/tPSA and prostate cancer in different range of tPSA, f/tPSA. We should choose notable hades to analyse in different range oftPSA, f/tPSA.

关 键 词：前列腺增生症 前列腺癌 前列腺特异性抗原 

分 类 号：R737.25[医药卫生—肿瘤]