解毒通腑、疏肝健脾法治疗介入性肝损害临床研究  

Therapoutic Effect of Therapy of Removing Toxins and Dredging Intestines,Soothing Liver and Strongthoning Spleen for Hepatic Injury by Intervention Therapy

作　　者：罗定新[1] 

机构地区：[1]广州中医药大学第一附属医院肿瘤中心,广东广州510405

出　　处：《新中医》2009年第8期18-19,共2页New Chinese Medicine

摘　　要：目的:观察解毒通腑、疏肝健脾法治疗介入性肝损害的临床疗效。方法:66例患者随机分为治疗组34例,对照组32例。治疗组以解毒通腑、疏肝健脾为法治疗,对照组采用多烯磷脂酰胆碱(Essential)治疗。自介入术后第2天起,每2天检测1次谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、谷氨酰转肽酶(GGT)、总胆红素(TBil)、直接胆红素(DBil)、间接胆红素(IBil),至指标最后一项恢复正常为止。同时,每天观察并纪录大便次数。结果:淤胆相关性指标TBil、DBil、IBil治疗过程中的峰值,治疗组明显低于对照组,差异有非常显著性意义(P<0.01);肝细胞损害相关性指标ALT、AST峰值,治疗组亦明显低于对照组,差异有显著性意义(P<0.05)。2组各指标恢复天数比较,差异均有非常显著性意义(P<0.01),治疗组天数明显少于对照组。治疗期间2组大便次数比较,差异有非常显著性意义(P<0.01),治疗组大便次数均明显多于对照组。结论:解毒通腑、疏肝健脾法能显著减轻介入性肝损害的程度,并显著缩短其恢复期。To observe the therapeutic effect of therapy of removing toxins and dredging intestines,soothing liver and strengthening spleen for hepatic injury induced by intervention therapy.Methods:Sixty-six patients were randomised into 2 groups:the treatment group (n=34) received therapy of removing toxins and dredging intestines,soothing liver and strengthening spleen,and the control group(n=32) received oral use of polyene phosphatidylcholine.From the second day of intervention,serum levels of alanine sminotransferase(ALT),aspartate aminotransferase (AST),alkaline phosphatase(ALP),glutamyltranspeptidase(CGT),total bilirubin (TBil),direct bilirubin(DBil),and indirect bilirubin(IBil) were detected every two days till all of the above parameters became normal.Meanwhile,the defection frequency was recorded every day.Results:The peak values of TBil,DBil and IBil in the treatment group were markedly lower than those in the control group,the difference being very significant between the two groups(P<0.01).So did the peak values of ALT and AST(P<0.05).The time for various parameters becoming normal was shortened,and the defection frequency was increased in the treatment group(P<0.01 compared with that in the control group).Conclusion:Therapy of removing toxins and dredging intestines,soothing liver and strengthening spleen is effective for relieving hepatic injury induced by intervention therapy,and can shorten the time for the recovery of hepatic function.

关 键 词：介入性肝损害 中药疗法 解毒通腑 疏肝健脾 

分 类 号：R575.1[医药卫生—消化系统]