中医辨证联合亚砷酸及沙利度胺治疗难治性多发性骨髓瘤临床观察  

Clinical Observation on Traditional Chinese Medical Syndrome Differentiation and Treatment Combined with Arsenite and Thalidomide for the Treatment of Refractory Multiple Myeloma

作　　者：杨宏光[1] 于天启[1] 陈志雄[1] 

机构地区：[1]广州中医药大学附属广州市中医医院血液科,广东广州510130

出　　处：《新中医》2009年第8期69-70,共2页New Chinese Medicine

摘　　要：目的:观察中医辨证用药联合亚砷酸、沙利度胺治疗难治性多发性骨髓瘤的疗效及其副作用。方法:6例患者均辨证地给予中药、沙利度胺联合亚砷酸化疗。观察血清C反应蛋白、β_2微球蛋白、M蛋白及骨髓瘤细胞等变化。结果:部分缓解4例,进步1例,无效1例(放弃治疗)。4例有骨痛症状者多在用药第1周后明显减轻,无须继续服止痛药,用药最好疗效时间为第2疗程后;2例贫血患者经治2疗程后,其中1例进步并无需输血,1例无效后放弃。除无效病例外,其余病例的生存质量均明显提高,日常生活自理状况改善。结论:辨证运用中药联合沙利度胺,配合亚砷酸化疗可作为复发/难治性多发性骨髓瘤的有效治疗方法。Objective:To observe the therapeutic effect and safety of traditional Chinese medical syndrome differentiation and treatment combined with arsenite and thalidomide for.the treatment of refractory multiple myeloma(RMM).Methods:Six RMM patienta received traditional Chinese medical syndrome differentiation and treatment combined with chemotherapy with arsenite and thalidomide.Serum levels of C-reactive protein,beta-2 microglobulin,M protein,and the decrease of myeloma cells were observed.Results:Of the six patients,4 were partially relieved,I was improved,and 1 was ineffective.The partially effective rate was 66.7%and the total effective rate was 83.3%.Osteodynis was relieved in 4 patients after treatment for one week;after two treatment courses,medication of analgesic was suspended in the 4 patients,and the therapeutic effect was the beat.One from two anemia patients did not need blood infusion,and one patient gave up treatment for being ineffective after two treatment courses.Except that the ineffective case,quality of life and activities of daily life in other cases were obviously improved.Conclusion:Traditional Chinese medical syndrome differentiation and treatment combined with arsenite and thalidomide is effective for the treatment of refractory multiple myeloma.

关 键 词：多发性骨髓瘤 中西医结合疗法 辨证论治 

分 类 号：R738.1[医药卫生—肿瘤]