新疆维吾尔族慢性胃炎人群中HLA-DRB1*08等位基因与幽门螺杆菌感染的关系  

Helicobacter pylori infection in Xinjiang Uygur nationality

作　　者：德里夏提.依米提 刘玉梅[2] 王亚男[3] 布海里且木.吾甫尔 刘素辉[3] 斯坎德尔.努尔买买提 

机构地区：[1]新疆医科大学病原生物学教研室,新疆乌鲁木齐830000 [2]新疆医科大学第一附属医院检验中心,新疆乌鲁木齐830000 [3]新疆医科大学形态中心,新疆乌鲁木齐830000 [4]新疆维吾尔自治区人民医院消化内科,新疆乌鲁木齐830000 [5]新疆维吾尔自治区人民医院胃肠外科,新疆乌鲁木齐830000

出　　处：《新疆医科大学学报》2009年第7期875-877,共3页Journal of Xinjiang Medical University

基　　金：新疆维吾尔自治区自然科学基金项目(编号:200521109)

摘　　要：目的:研究新疆维吾尔族慢性胃炎人群HLA DRB1*08等位基因与幽门螺杆菌感染的关系。方法:采用幽门螺杆菌分离培养技术检测慢性胃炎汉族36例,维吾尔族33例人群的幽门螺杆菌感染情况,并采用PCRSSP检测HLA-DRB1*08等位基因。结果:(1)新疆维吾尔族慢性胃炎人群H.pylori(Hp)阳性率为79%,高于汉族慢性胃炎人群(56%)(P<0.05)。(2)两组慢性胃炎人群Hp阳性组中HLA-DRB1*08等位基因频率在汉族为10.0%,在维吾尔族为15.4%,HLA-DRB1*08等位基因在汉族与维吾尔族慢性胃炎人群中检出频率无差异,维吾尔族与汉族慢性胃炎人群中HLA DRB1*08等位基因与Hp感染无关(P>0.05)。结论:(1)维吾尔族Hp感染率高于汉族慢性胃炎人群(P<0.05)。(2)维吾尔族与汉族慢性胃炎人群中HLA DRB1*08等位基因与H.pylori感染率无关。Objective： To compare the prevalence of H. pylori infection in gastritis of Xinjiang Uygur, Han ethnic groups, and to analyze the association of HLA-DRB1 ＊ 08 allele of these two ethnic groups gastritis with H. pylori infection. Methods： Diagnosis by isolation of Hp from gastric biopsies for 36 Han and 33 Uygur chronic gastritis. Polymorase chain reaction single strand polymorphism （PCR-SSP） technique was applied to determine the polymorphism of the HLA-DRB1 ＊ 08 locus of these groups and the association of HLA-DRB1 ＊ 08 allele of these groups with Hp infection was analyzed by SPSS software. Results： The prevalence of Hp infection was 56% in Han nationality which was lower than the Uygur nationality （79%） （P 〈0. 05）. The distribution of HLA-DRB1 ＊ 08 locus was not significantly different between the 2 groups （P 〉0. 05）. Conclusion： The results indicated that the prevalence of Hp infection in Han and Uygur ethnic groups in Xinjiang Uygur was higher than that in Han ethnic group. HLA-DRB1 ＊ 08 allele have no relationship with Hp infection.

关 键 词：HLA—DRB1＊08等位基因 幽门螺杆菌 幽门螺杆菌感染 慢性胃炎 

分 类 号：R573[医药卫生—消化系统] R816.1[医药卫生—内科学]