食管癌患者放疗前后血清sIL-2R和TNF-α水平测定及其临床意义  

Clnical significance of measurements of serum sIL-2R and TNF-α-levers in patients with carcinoma of esophagus before and after radiotherapy

作　　者：许梅[1] 杨朝群[2] 

机构地区：[1]石河子大学医学院 [2]石河子大学医学院第一附属医院放疗科,新疆石河子832008

出　　处：《农垦医学》2009年第3期211-213,共3页Journal of Nongken Medicine

摘　　要：目的:探讨食管癌患者放疗前后血清可溶性白细胞介素-2受体(sIL-2R)和肿瘤坏死因子-α(TNF-α)水平的变化。方法:双抗体夹心ELISA法测定30例食管癌患者放疗前后sIL-2R含量,用放免法测定30例食管癌患者放疗前后血清TNF-α含量并与25名正常人作比较。结果:食管癌患者在放疗前血清中sIL-2R和TNF-α含量显著地高于正常人组(P<0.05),放疗后明显下降(P<0.05)。结论:食管癌患者血清中sIL-2R和TNF-α水平明显增高,放疗后明显下降,血清sIL-2R和TNF-α水平对食管癌患者疗效及免疫功能判断有一定参考价值。Objective： To study the changes of serum soluble interleukin-2 receptor（sILo2R） and tumor necrosis factor-α （TNF-α） levels after radiotherapy in patients with carcinoma of esophagus. Methods：Serum sIL-2R and TNF-α levels were measured in 30 patients with carcinoma of esophagus both before and after radiotherapy as well as in 30 healthy person. Results： Before radiotherapy, the levels of serum sIL-2R and TNF-α were significantly higher in 30 patients with carcinoma of esophagus than those in the 25 healthy person（ P 〈 0.05 ）. After radiotherapy , levels of serum slL-2R and TNF-α were decreased significantly as compared with that of patients before radiopherapy. Conclusion ：The serum sIL-2R and TNF-α levels can reflect immune status of patients with carcinoma of esophagus and provide a useful reference for evaluation of radiotherapy effect.

关 键 词：食管癌 放疗 可溶性白细胞介素-2受体 肿瘤坏死因子-Α 

分 类 号：R73-3[医药卫生—肿瘤]