犬空肠动脉栓塞安全性的实验研究  

Experimental Study of Safety of the Embolization of Jejunal Artery in Dogs

作　　者：唐郁宽[1] 史瑞雪[1] 陈勇[2] 曾庆乐[2] 陈广源[1] 黄小英[1] 李晶[1] 邓炜[1] 胡佩玲[1] 曹筱莹[1] 刘海英[1] 陈汉威[1] 

机构地区：[1]广州市番禺区人民医院,广州511400 [2]南方医科大学附属南方医院介入科,广州510515

出　　处：《热带医学杂志》2009年第7期738-741,共4页Journal of Tropical Medicine

基　　金：广州市番禺区科技局科技攻关项目(No.2003-Z-19-1)

摘　　要：目的通过超选择性插管入犬空肠动脉分支后用聚乙烯醇(polybviny lalcohol particles,PVA)颗粒栓塞,观察肠壁缺血坏死程度和范围,探讨其安全性。方法44只犬随机分为A、B两组。A组(22只):空肠动脉二级分支水平远端栓塞;B组(22只):空肠末级动脉弓前一级分支水平栓塞。分别注入大小为150～250μm(A1组6只,B1组6只)、355～500μm(A2组8只,B2组8只)和710～1000μm(A3组8只,B3组8只)PVA颗粒。少量、缓慢、间断推注PVA,血流停滞时即停止。术后3、7、14d,处死犬取出空肠行大体及病理学观察。结果栓塞技术成功率为95.5%。PVA颗粒量为5～10mg。注入150～250μm、355～500μm、710～1000μmPVA颗粒肠坏死的发生率分别为:81.8%(9/11)、40.0%(6/15)、25.0%(4/16),组间差异具有统计学意义(P<0.05)。A、B两组发生肠坏死的发生率分别为61.9%(13/21)、28.6%(6/21),组间差异有统计学意义(P<0.001)。结论在同一栓塞水平下,PVA颗粒越小则越易发生肠坏死。最佳的栓塞水平在末级动脉弓前一级分支水平,PVA颗粒大小应选择710～1000μm。Objective To investigate the extent of intestinal necrosis after embolization of jejunal artery branches with polybvinyl alcohol particles （PVA）. Methods Forty-four dogs were randomly divided into two groups, Group A （n=22） and Group B （n=22）. Jejunal artery branches were embolized at the second level and the level prior to arterial arcade. PVAs with a size of 150-250 μm, 355-500 μm, 710-1 000 μm were injected slowly and intermittently until the stasis of blood. Jejunum was removed and prepared for pathological study at day-3, 7 and 14 after embolization. Results The success rate of embolization was 95.5%. The dosage of PVA was ranged from 5 mg to 10 mg. The necrosis rate of jejunum embolized with 150-250 μm, 355-500 μm, 710-1 000 μm PVA was 81.8%, 40%,25%, respectively, and the the results were significantly different between groups （P〈0.05）. The necrosis rate of Group A （61.9%） was significantly different from Group B（28.6%, P〈0.001）. Conclusion Embolization at the same branch level with a smaller size of PVA resulted in a higher necrosis rate. The preferred embolizing site was located at the branch level prior to arterial arcade and the appropriate diameter of PVA was 710-1 000 μm.

关 键 词：空肠 栓塞 实验 

分 类 号：R57[医药卫生—消化系统]