Syk在不同乳腺病变组织中的表达及临床意义  

Expression of Syk in different breast lesions and their clinical significance

作　　者：赵鹏[1] 王红鹰[1] 邹强[1] 唐峰[2] 周坚[1] 金贻婷[1] 劳正胤[1] 

机构地区：[1]复旦大学上海医学院附属华山医院普外科,上海200040 [2]复旦大学上海医学院附属华山医院病理科,上海200040

出　　处：《外科理论与实践》2009年第4期403-406,共4页Journal of Surgery Concepts & Practice

摘　　要：目的:探讨不同乳腺病变组织中脾酪氨酸激酶(Syk)表达差异,并分析Syk表达与乳腺癌临床及其他病理学指标的关系。方法:用免疫组化法检测20例纤维囊性乳腺病组织、16例乳腺DIN2组织(导管原位癌,中级别)、168例乳腺浸润性导管癌组织及95例癌旁组织中Syk蛋白的表达,并检测乳腺癌组织中ER、PR、p53、HER2/neu表达。结果:纤维囊性乳腺病组织、乳腺DIN2组织、乳腺癌组织及其癌旁组织中Syk阳性表达率分别为90.00%(18/20例)、50.00%(8/16例)、34.52%(58/168例)及78.95%(75/95例)。乳腺癌组织中Syk阳性表达率较纤维囊性乳腺病组织(P<0.05)及乳腺癌旁组织(P<0.05)明显降低。乳腺DIN2组织中Syk阳性表达率较纤维囊性乳腺病组织(P<0.05)及乳腺癌旁组织(P<0.05)明显降低。Syk表达与肿瘤大小、组织学分级、淋巴结转移、肿瘤分期及ER、PR、p53、HER2/neu表达结果均无相关性。结论:Syk在纤维囊性乳腺病、癌旁组织、癌前期病变和乳腺癌组织中的阳性表达率依次降低。Objective To evaluate the difference in Syk expression in different breast lesions, and to study the correlation of expression of Syk in breast cancer with other clinicopathologic markers. Methods Immunohistochemistry was used to detect Syk protein expression in cases of different breast lesions, consisting of 20 cases of fibrocystic disease of the breast, 16 cases of ductal intraepithelial neoplasia 2 （DIN2） and 168 cases of breast cancer and 95 specimens of pericancer tissue obtained at a distance of 5 cm from the cancer tissue. Concomittantly, ER, PR, p53, HER2/neu were detected in 168 breast cancer tissue with immunohistochemical staining. Results The positive rates of Syk expression were 90.00% （18/20）, 50.00%（8/16）, 34.52%（58/168） and 78.95%（75/95） respectively in fibrocystic breast disease tissue, DIN2 tissue, breast cancer tissue and peri-eaneer tissue. The positive expression rates of Syk were significantly lower in the breast cancer tissue than those in the fibrocystic breast disease tissue （P〈0.05） and the peri-cancer tissue （P〈0.05）; and significantly lower in the DIN2 tissue than those in the fibrocvstic breast disease tissue （P〈0.05） and the neri-cnncor tissue （P〈0.05）. The correlation between reduction of Syk expression in breast cancer tissue and the other clinicopathologic factors or prognostic markers was not found in our study. Conclusions The positive rates of Syk expression progressively decrease from the fibrocystic disease tissue, peri-cancer tissue, pre-cancer lesion to the cancerous tissue in the breast.

关 键 词：脾酪氨酸激酶(Syk) 人乳腺 癌 癌前状态 纤维囊性乳腺病 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]