移植免疫耐受的研究现状及进展  

Immune tolerance of transplantation

作　　者：郁华亮[1] 肖序仁[2] 

机构地区：[1]解放军总医院第一附属医院泌尿外科,北京市100037 [2]解放军总医院泌尿外科,北京市100853

出　　处：《中国组织工程研究与临床康复》2009年第31期6109-6112,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目前,器官移植已经成为终末期器官功能衰竭患者的有效治疗手段,但长期使用免疫抑制剂可引起许多不良反应,而且免疫抑制剂无助于移植慢性排斥反应和移植物的长期存活。器官移植后最理想的措施是针对供体移植物建立特异性免疫耐受,树突状细胞、CD4+CD25+调节性T细胞及嵌合现象等在免疫耐受过程中都扮演了重要的角色。目前为止还未形成一种成熟的可以在临床广泛应用的移植免疫耐受模式,理想的免疫耐受模式还有待进一步探索。Organ transplantation is a routine clinical procedure for patients with end-stage organ failure. AIIograft rejection remains one of major complications after organ transplantation. Moreover, it is helpless for chronic rejection and graft＇s long-term surviving. After transplantation, ideal therapeutic mode is to establish specific immune tolerance for graft. Dendritic cell, CD4^＋CD25^＋ regulatory T cell and chimerism have played important roles in the formation of immune tolerance. So far, a ripe mode of immune tolerance that can be applied to clinic extensively has not been formatted, which needs to further explored.

关 键 词：免疫耐受 树突状细胞 CD4+CD25+调节性T细胞 嵌合现象 

分 类 号：R730[医药卫生—肿瘤]