鼻咽癌放射治疗后脑损伤49例临床分析  

Radiation Injury in the Brain after Radiotherapy for Nasopharyngeal Carcinoma

作　　者：刘鹊凌[1] 孙爱民[1] 苏宁[2] 刘英[1] 陈龙华[1] 袁亚维[1] 

机构地区：[1]南方医科大学南方医院放疗科,广州市510515 [2]南方医科大学南方医院肿瘤中心,广州市510515

出　　处：《中国肿瘤临床》2009年第14期781-783,共3页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金资助(编号:39870225)~~

摘　　要：目的:分析鼻咽癌放射性脑损伤的临床特点及预后因素。方法:回顾性分析1998年1月至2006年6月我院收治的49例鼻咽癌放射性脑损伤患者的临床资料。结果:鼻咽癌单程放疗及再程放疗放射性脑损伤的发生率分别为2.31%(30/1298),9.64%(19/197)(P<0.05)。单程放疗及再程放疗放射性脑损伤的中位潜伏期分别为50.5个月与25.5个月(P<0.05)。颞叶型、脑干型及混合型放射性脑损伤所占的比例分男11为75.5%(37/49)、18.4%(9/49)、6.1%(3/49)。经积极对症治疗后,放射性脑损伤的症状及体征有所改善,但生活质量明显下降。结论:鼻咽癌放射性脑损伤与射野的设计相关,放射性脑损伤以颞叶型发生率较高,再程放疗放射性脑损伤的发病率最高,且潜伏期明显缩短。Objective： To study the clinical features and prognostic factors of brain injury after radiotherapy for nasopharyngeal carcinoma （NPC）. Methods： From January 1998 to June 2006, 49 NPC patients with post-radiation brain injury in our hospital were analyzed retrospectively. Results： The incidence of post-radiation brain injury after single-pass radiotherapy and re-course radiotherapy was 2.31% and 9.64%, respectively （P〈0.05）. The median latency period was 50.5 months for single-pass radiotherapy and 25.5 months for re-course radiotherapy. Fourty-nine patients suffered from radiation injury in the brain. The lesions were located in the temporal lobe in 37 patients （75.5%）, in the ports in 9 patients （18.4%） and in mixed position in 3 patients （6.1%）. The symptoms and signs of the patients could be.alleviated by therapy, but the quality of life was not improved. Conclusion： Radiation brain injury in NPC patients after radiotherapy is related to field design. The incidence of radiation brain injury in the temporal lobe is the highest. Compared with single-pass radiotherapy, re-course radiotherapy leads to higher incidence of brain injury and shorter latency period.

关 键 词：鼻咽肿瘤 脑 放射性损伤 

分 类 号：R739.63[医药卫生—肿瘤] R722.120.6[医药卫生—临床医学]