急性胰腺炎患者血清部分细胞因子水平的变化  

Study on changes of cytokines in patients with acute pancreatitis

作　　者：黄超群[1] 朱伟东[2] 钟耀区[3] 叶彩丽[4] 

机构地区：[1]惠州市人民医院检验科,广东省惠州516002 [2]惠州市人民医院普外科,广东省惠州516002 [3]惠州市人民医院重症监护科,广东省惠州516002 [4]惠州市中心人民医院检验科

出　　处：《中国基层医药》2009年第7期1157-1158,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨急性胰腺炎（AP）患者血清肿瘤坏死因子-α（TNF—α）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、血小板活化因子（PAF）、血管紧张素-Ⅱ（AGT-Ⅱ）的水平变化。方法60例AP患者分为重症急性胰腺炎（SAP）组30例，轻型急性胰腺炎（MAP）组30例，另选健康对照组30例。应用ELISA法和放射免疫法测定血清TNF-α、IL-6、IL-8、PAF、AGT-Ⅱ比较观察三组间的水平变化。结果SAP组（急性期，恢复期）和MAP组（急性期，恢复期）TNF-α、IL-6、IL-8、PAF、AGT-Ⅱ水平均明显高于健康对照组（均P〈0．01）；SAP组急性期TNF-α、IL-6、IL-8、PAF、AGT—Ⅱ水平均明显高于MAP组（均P〈0．05）；SAP组和MAP组恢复期TNF-α、IL-6、IL-8、PAF、AGT-Ⅱ水平均明显低于急性期（均P〈0．05）；SAP组死亡者TNF-α、IL-6、IL-8、PAF、AGT-Ⅱ水平均明显高于生存者（均P〈0．05～0．01）。结论TNF-α、IL-6、IL-8、与SAP的病情严重程度及预后密切相关，SAP组AGT-Ⅱ水平升高较MAP组明显。Objective To study the clinical significance and changes of serum TNF-α, IL-6, IL-8, PAFand AGT-Ⅱ in patients with severe acute pancreatitis（SAP）. Methods Serum TNF-α,IL-6,IL-8,PAF, AGT-Ⅱ values of all patients were measured by ELISA and radioimmunoassay. 30 cases with mild AP（ MAP group） ,50 cases with SAP（SAP group） and 30 non-pancreatitis patients as control group. Results The level of TNF-α, IL-6, IL-8, PAF, AGT-Ⅱ of acute phase and recovery phase in SAP group and the MAP group were significantly higher than the normal control group（ all P 〈 0. 01 ） ; the level of TNF-α,IL-6,IL-8,PAF and AGT-Ⅱ of acute phase in SAP group were significantly higher than the MAP group（ all P 〈 0. 05 ） ; the level of TNF-α,IL-6,IL-8 ,PAF and AGT-Ⅱ of recovery phase in SAP group were significantly lower than the acute phase（ all P 〈 0. 05 ） ;the level of TNF-α,IL-6,IL- 8, PAF and AGT-Ⅱ of died in SAP group were significantly higher than the survivors （ all P 〈 0. 05 - 0. 01 ）. Conclusion The level of TNF-α,IL-6,IL-8 with the severity of SAP＇s condition and prognosis is closely related, The level of AGT-Ⅱ in SAP group were significantly higher than the MAP group.

关 键 词：胰腺炎 肿瘤坏死因子-α 白细胞介素 血小板活化因子 肾素 血管紧张素-Ⅱ 

分 类 号：R57[医药卫生—消化系统]