血清细胞因子与脑血流灌注显像在原发性癫痫中的相关性分析  

Correlation analysis of serum cytokines and regional cerebral blood flow image in primary epilepsy

作　　者：杨德本[1] 张涛[2] 张国元[3] 

机构地区：[1]川北医学院附属医院神经内科,南充637000 [2]川北医学院附属医院核医学科,南充637000 [3]川北医学院附属医院检验科,南充637000

出　　处：《重庆医学》2009年第16期2016-2017,共2页Chongqing medicine

摘　　要：目的探讨原发性癫痫患者治疗前后血清细胞因子白细胞介素-2(IL-2)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平变化及其与局部脑血流量(rCBF)变化的相关性。方法采用酶联免疫吸附法(ELISA)检测22例原发性癫痫患者治疗前、抗癫痫治疗3个月后、对照组血清IL-2、IL-6、TNF-α、rCBF。结果癫痫患者治疗前血清IL-2、IL-6及TNF-α水平明显高于对照组(P<0.01),而rCBF明显低于对照组(对照组未发现rCBF下降);治疗后血清IL-2、IL-6及TNF-α水平明显低于治疗前(P<0.01),而rCBF明显高于治疗前。结论癫痫患者存在细胞免疫功能紊乱,临床药物治疗对细胞因子水平有影响。rCBF检查是一种检测癫痫的敏感技术,发作间期rCBF检查可有效预测疗效。Objective To observe the change of varied cytokines interleukin（IL）-2,interleukin（IL）-6 and tumor necrosis factor alpha（TNF-α） and their correlation with regional cerebral blood flow（rCBF） before and after treatment. Methods ELISA was used to measure serum IL-2,IL-6 and TNF-α before treatment and after 3 month treatment in 22 cases of primary epilepsy and 18 cases in control group. The data of detection results were compared in two groups. Results The levels of IL-2 ,IL-6 and TNF-α in the epilepsy group before treatment were significantly higher than those in the control group（P（0.01）, but rCBF was obviously lower. The levels of IL-2,IL-6 and TNF-α in the epilepsy group after treatment were lower than those before treatment, while rCBF signif icantly higher than before treatment. There was a positive correlation between cytolines （IL-2, IL-6 and TNF-α） and rCBF（P（ 0.01）. Conclusion The patient with epilepsy has cytommunity disorder. Drug treatment affects the cytokines levels, rCBR determination is a sensitive technique to detect epilepsy and rCBF performed in epileptic seizure can predict the treatment curative effective- ly.

关 键 词：癫痫 白细胞介素2 白细胞介素6 肿瘤坏死因子α 局部脑血流量 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R741.04[医药卫生—临床医学]