Synthesis of novel 15-membered macrolide dimers  

作　　者：Shu Tao Ma Rui Xin Ma Rui Qing Xian Bo Jiao 

机构地区：[1]School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China [2]Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China [3]Shandong Institute for Drug Control, Jinan 250000, China

出　　处：《Chinese Chemical Letters》2009年第8期931-934,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.2087208 1);Natural Science Foundation of Shandong(No.Y2006C3 1);Shandong Science and Technology Promotion Project(No.2005GG3202098).

摘　　要：A series of novel dimers of 15-membered macrolides was synthesized and evaluated. The dimers exhibited excellent activity against erythromycin-susceptible S. pneumonia, but did not show any improved activity against erythromycin-resistant S. pneumoniae encoded by erm gene. ？2009 Shu Tao Ma. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.A series of novel dimers of 15-membered macrolides was synthesized and evaluated. The dimers exhibited excellent activity against erythromycin-susceptible S. pneumonia, but did not show any improved activity against erythromycin-resistant S. pneumoniae encoded by erm gene. ？2009 Shu Tao Ma. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.

关 键 词：MACROLIDE Azithromycin derivatives D/mers SYNTHESIS 

分 类 号：Q513[生物学—生物化学] S859.796[农业科学—临床兽医学]