3-[(2-二甲基氨甲基)环己基]苯基乙酸酯盐酸盐的合成  

Synthesis of 3-[2-(Dimethylaminomethyl)cyclohexyl]phenyl Acetate Hydrochloride

作　　者：蒋忠良[1] 靳向乐[1] 湛明[1] 李铃春[1] 宗杰[1] 

机构地区：[1]同济大学化学系,上海200092

出　　处：《合成化学》2009年第4期506-507,共2页Chinese Journal of Synthetic Chemistry

摘　　要：以盐酸曲马多为起始原料,通过脱羟基,去甲基和乙酰化反应合成了一种新化合物3-[(2-二甲基氨甲基)环己基]苯基乙酸酯盐酸盐,其结构经1HNMR,MS和元素分析表征。A novel compound, 3-[ 2-（dimethylaminomethyl） cyclohexyl] phenyl acetate hydrochloride, was synthesized from tramadol hydrochloride by dehydroxyladon, demethylation and acetylation. The structure was characterized by ^1H NMR, MS and elemental analysis.

关 键 词：盐酸曲马多 抗抑郁 药物合成 

分 类 号：R914.5[医药卫生—药物化学] O624.6[医药卫生—药学]