伽玛刀治疗后C-myc蛋白在复发胶质瘤中表达的变化及意义  

Expression changes of C-myc protein in recurrent glioma after gamma knife treatment and its significance

作　　者：张列[1,2] 张道宝 毛庆[1] 王恩任[2] 樊庆荣[2] 邱治春[2] 

机构地区：[1]四川大学华西医院神经外科,四川成都610041 [2]成都医学院第一附属医院神经外科,四川成都610500

出　　处：《中华神经外科疾病研究杂志》2009年第4期350-353,共4页Chinese Journal of Neurosurgical Disease Research

基　　金：四川省科技攻关基金资助项目(05SG022-001-2)

摘　　要：目的探讨伽玛刀(γ-刀)治疗后C-myc蛋白在复发胶质瘤中表达的变化及意义。方法用免疫组化SP法检测29例复发胶质瘤患者(γ-刀治疗组12例,非伽玛刀治疗组17例)在初发肿瘤组织和复发肿瘤组织中C-myc蛋白的表达。结果非γ-刀治疗组中,C-myc蛋白在初发胶质瘤中的表达明显低于其在复发胶质瘤中的表达(P<0.05)。γ-刀治疗组中,C-myc蛋白在初发胶质瘤中的表达明显高于其在复发胶质瘤中的表达(P<0.05)。γ-刀治疗组肿瘤复发时间的中位数为10.5个月,非γ-刀治疗组肿瘤复发时间的中位数为6个月,两组复发时间比较有显著性差别。结论γ-刀治疗胶质瘤,可能通过抑制C-myc的表达产生作用,并延长肿瘤的复发时间。Objective To investigate the expression changes of C-myc protein in recurrent glioma after gamma knife treatment and its significance. Methods The expression of C-myc protein in the primary and recurrent glioma tissues of 29 recurrent glioma patients （there are 12 patients in the gamma knife treatment group and 17 patients in the non-gmma knife treatment group）were detected by immunohistochemical staining. Results In the non-gamma knife treatment group, the expression of C-myc protein in the primary gliomas was lower than that in the recurrent gliomas（P 〈 0.05）. In the gamma knife treatment group, there was significant difference in the expression of C-myc protein in the primary, gliomas and recurrent gliomas with a higher level in the primary gliomas （P 〈0.05）. There was significant difference in the recurrent time between ganuna knife treatment group and non-gamma knife treatment group （ 10.5months vs. 6 months）. Conclusion The gamma knife treatment may be realized by inhibiting the expression of C-myc protein and it also can extend the recurrent time of gliomas.

关 键 词：胶质瘤 Γ-刀 C-MYC 免疫组化染色 

分 类 号：R739.4[医药卫生—肿瘤]