CXCL12/CXCR4生物学轴诱导前列腺癌骨转移的作用机制研究进展  

Advance in the research of the mechanism of CXCL12/ CXCR4 axis induced osseous metastasis of prostate cancer

作　　者：杨晨[1] 姚阳[1] 

机构地区：[1]上海市交通大学附属第六人民医院肿瘤内科,上海200233

出　　处：《现代肿瘤医学》2009年第8期1599-1601,共3页Journal of Modern Oncology

基　　金：上海市市级医学慢性病综合防治项目资助(SHDC12007304)

摘　　要：研究发现趋化因子CXCL12(Stromal-derived factor-1,SDF-1)和受体CXCR4[chemokine(C-X-Cmotif)receptor4]广泛表达于组织和器官上,相关的研究发现其与前列腺癌细胞的黏附、侵袭、增殖和生存有关,并认为其在前列腺癌骨转移的发生中发挥重要作用。通过阐明CXCL12/CXCR4生物学轴和前列腺癌骨转移之间的关系,从而寻找有助于疾病治疗的新途径。CXCL12 （ stromal - derived factor - 1, SDF - 1 ） and its receptor CXCR4 （ chemokine （ C - X - C motif） receptor 4） were demonstrated to be widely expressed in a broad array of tissues and organs. Recent studies suggested that CXCL12/CXCR4 axis was related to the adhesion, invasion, proliferation and survival of prostate cancer cells, and played an important role in bone metastasis. Elucidating the relationship between the CXCL12/CXCR4 axis and the development of bone lesion of prostate cancer is helpful to find a new way to treat the disease.

关 键 词：CXCL12 CXCR4 前列腺癌 骨转移 

分 类 号：R737.25[医药卫生—肿瘤]