鼻咽癌CT、MRI颅底骨成像差异患者两种放疗方案对脑组织受照射状况影响的模拟研究  被引量:1

A simulation study on the impact of two different radiotherapy plans on radiation situation of the brain of patients with nasopharyngeal carcinoma with magnetic resonance imaging and computed tomography image difference in cranial base

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作  者:秦岭[1] 李龄[2] 王安宇[2] 

机构地区:[1]广西壮族自治区人民医院神经内科,南宁530021 [2]广西医科大学附属肿瘤医院放疗科,南宁530021

出  处:《中国临床新医学》2009年第7期666-669,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基  金:广西医疗卫生重点科研课题基金项目(编号:200520)

摘  要:目的研究鼻咽癌放射治疗中不同的照射剂量对CT与MRI颅底骨成像差异患者脑组织的影响。方法对MRI与CT颅底骨成像差异病例26例,分别根据MRI与CT成像信息应用ARTP—TOP 3D—TPS系统制定三维适形计划,比较两计划脑组织平均剂量和D5平均剂量。结果MRI计划中的脑干、垂体、左右颞叶和左右眼球的平均剂量(Gy)(47.01±4.61,59.59±8.80,5.92±3.72,6.55±3.80,38.27±6.15,38.78±7.52)计划大于CT计划中各个相应器官的平均剂量(Gy)(34.66±4.99,52.11±7.15,5.66±3.95,6.36±4.11,29.94±5.69,30.23±6.54)(P〈0.05)有统计学意义;两个计划中脊髓平均剂量(Gy)(MRI 29.51±5.80,CT30.30±4.04)比较无统计学意义;MRI计划中的脑干、脊髓、垂体、左右颞叶、左右眼球的D5平均剂量(Gy)(66.15±3.43,44.26±4.35,61.59±8.89,20.65±10.66,20.09±11.65,67.60±2.39,67.31±6.88)均大于CT计划中相应器官的D5平均剂量(Gy)(56.49±2.52,41.51±4.65,54.04±7.31,20.17±10.47,19.37±11.44,60.69±3.62,60.04±6.84)(P〈0.05)。结论根据MRI制定的三维适形计划,肿瘤靶区的剂量覆盖较CT好,但是对脑组织的照射剂量相对CT的较高。Objective To study the impaet of the treating dose of target volume in different radiotherapy plans on radiation situation of the brain of patients who suffer from nasopharyngeal carcinoma (NPC) with magnetic resonance imaging (MRI) and computed tomography(CT) image differenee in cranial base. Methods According to the MR/and CT image difference in cranial base, we applied ARTP -TOP3D -rIPS system to delineate target volume and develop the three - dimensional conformal radiotherapy (3 - DCRT) plans. Tewenty - six NPC patients were treated by the 3 - DCRT plans. The mean dose and 195 mean dose of the target volume in the two group ( CT based plan and MR/based plan) were compared. Results Compared with CT based plan (34. 66±4.99 ) Gy, (52. 11± 7. 15 ) Gy, (5. 66 ±3.95 ) Gy, ( 6. 36±4. 11 ) Gy, ( 29. 94±5.69 ) Gy, ( 30.23± 6.54 ) Gy, the mean dose of brainstem, pituitary, temporal lobe and both eyes in MR1 based plan(47.01 ±4. 61 ) Gy, (59.59 ± 8.80) Gy, (5.92 ± 3. 72) Gy, (6. 55 ± 3.80) Gy, (38.27 ± 6. 15 ) Gy, (38.78 ± 7.52 ) Gy were larger (P 〈 0. 05 ). There was no statistic difference in the mean dose of spinal cord between two plans [ MRI ( 29. 51 ± 5.80 ) Gy, CT ( 30. 30 ± 4. 04 ) Gy ]. Compared with CT based plan(56.49 ± 2. 52) Gy, (41.51 ± 4. 65) Gy, (54.04 ± 7. 31 ) Gy, (20. 17 ± 10. 47) Gy, (19. 37 ± 11.44)Gy, (60. 69 ±3.62) Gy, (60. 04±6. 84) Gy, the D5 mean dose of brainstem, spinal cord, pituitary, temporal lobe and both eyes in MR/ based plan ( 66. 15 ±3.43 ) Gy, ( 44.26±4. 35 ) Gy, ( 61. 59 ±8. 89 ) Gy, ( 20.65±10. 66) Gy, ( 20. 09±11.65 ) Gy, ( 67.60± 2. 39) Gy, ( 67.31±6. 88 ) Gy were larger ( P 〈 0. 05 ). Conclusion The dose of target volume in 3D - CRT plan based MR] is superior to CT. The dose of important organ of the brain in 3D - CRT plan based MRI is higher.

关 键 词:鼻咽癌 放射治疗 CT MRI 

分 类 号:R739.63[医药卫生—肿瘤]

 

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