CD44v6表达与乳腺癌生物学特性关系的研究  

A study on the relationship between CD44v6 expression and biological characteristics in breast cancer

作　　者：张还珠[1] 董伟华[2] 刘芯[1] 黄振倩[1] 谭获[1] 

机构地区：[1]广州医学院第一附属医院肿瘤血液中心,510230 [2]广州医学院病理生理教研室

出　　处：《中国临床实用医学》2009年第8期6-8,共3页China Clinical Practical Medicine

基　　金：广东省科技厅立项项目（项目编号：20078031515016）

摘　　要：目的探讨粘附分子CD44v6的表达情况及其与乳腺癌相关生物学特性的关系。方法用免疫组织化学法检测本院2006年收治的65例乳腺癌女患者的病理标本CD44v6表达，并评价肿瘤相关生物学特性的情况。结果65例乳腺癌患者中CD44v6呈阳性反应有53例，占81．5％；有腋窝淋巴结转移的病例CD44v6阳性率（90．9％）明显高于无腋窝淋巴结转移病例CD44v6阳性率（61．9％）（P〈0．01）；Ki-67表达阳性患者其CD44v6阳性率为76．9％，Ki-67表达阴性患者无CD44v6阳性表达（P〈0．01）；CD44v6表达的多元logistic回归分析显示：腋窝淋巴结转移情况（OR=1．604）和Ki-67表达（OR=2．800）是CD44v6表达的主要影响因素。结论CD44v6的表达与腋窝淋巴转移情况及Ki-67表达情况密切相关，CD44v6是检测乳腺癌病情和判断预后的一个重要指标。Objective To investigate the correlative relationship between the expression of adhesion molecule CD44v6 and biological characteristics of breast cancer. Methods Using immunhistochemieal techniques ,we examined the expression of CD44v6 in 65 specimens of breast cancer patients ,who were diagnosed in our hospital in 2006, and assessed about biolegical characteristics of the tumor. Results Fifty-three of sixty-five （81.5%） women with breast carcinoma were CD44v6 positive. The positive rate of CD44v6 in cases with metastases of axillary nodes was significantly higher than that without metastases of axillary nodes （90.9% vs 61.9% ,P 〈0. 01 ）. The positive rate of CD44v6 in cases with Ki-67 expression was 76.9% ,and there is no expression of CD44v6 in cases of Ki-67 negative （ P 〈 0.01 ）. In multivariate analysis, using the Logistic model, the main factors on CD44v6 expression were metastases of axillary nodes （OR = 1. 604）and Ki-67 expression （OR = 2. 800）. Conclusion CD44v6 expression was closely correlated with metastases of axillary nodes and Ki-67 expression. It is an important indicator of detecting patient＇ s condition and predicting patient＇ s prognosis in breast cancer.

关 键 词：乳腺癌 CD44V6 生物学特性 

分 类 号：R737.9[医药卫生—肿瘤]