肿瘤标志物在食管鳞状细胞癌中的研究与应用  

Research and application of tumor markers in esophageal squamous cell carcinoma

作　　者：王皓[1] 钟理[1,2] 王建飞[1] 张小刚[1] 

机构地区：[1]河北大学生命科学学院生物芯片研究室 [2]City of Hope National Medical Center,Duarte,California91010,USA

出　　处：《世界华人消化杂志》2009年第18期1842-1848,共7页World Chinese Journal of Digestology

摘　　要：食管鳞状细胞癌作为食管癌的主要类型,是人类最常见的消化系恶性肿瘤之一.作为诊断手段之一的肿瘤标志物检测,具有简便、经济、快速、无创的特点,更重要的是一些标志物在组织器官发生形态学变化之前就有表达,因此,肿瘤标志物对食管癌的研究就更有意义.本文综述近几年来一些发现和检测到的肿瘤标志物在食管鳞状细胞癌中的差异表达,分别从基因、蛋白、自身免疫抗体、抗原及预测因子角度总结介绍.Esophageal squamous cell carcinoma （ESCC）, the main type of esophageal cancer, is one of the most common gastrointestinal malignant cancers. Tumor markers detection are easy, economical, fast and non-invasive. Some tumor markers can be expressed before morphological changes occurred in tissues and organs; therefore, they can be used for the diagnosis of disease in the asymptomatic stage, thus making the research into tumor marker discovery even more meaningful. This paper summarizes several known tumor makers’ expression detected in ESCC in recent years, and illustrates them from the aspects of genes, proteins, autoimmune antibodies, antigens and prognostic factors.

关 键 词：食管鳞状细胞癌 肿瘤标志物 基因表达 甲基化 自身免疫抗体 

分 类 号：R735.1[医药卫生—肿瘤]