MELAS综合征的MRI诊断  

MRI diagnosis of MELAS syndrome

作　　者：王凤月[1] 徐俊玲[1] 李永丽[1] 张继良[1] 

机构地区：[1]河南省人民医院放射科,郑州450003

出　　处：《中国实用神经疾病杂志》2009年第15期20-22,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨线粒体脑肌病MELAS综合征的MRI表现特点。方法回顾分析11例经病理证实的MELAS综合征患者的临床及MRI检查资料。结果11例患者MRI表现均显示多叶受累的大脑皮质及皮质下异常信号,病变不按血管支配区分布,且具有多变性,增强扫描少有强化,MRA无大血管狭窄。9例为双侧病变,2例为单侧;T1WI呈等信号或低信号,T2WI呈高信号;其中枕叶受累9例,顶叶受累7例,颞叶受累6例,额叶受累2例;伴发脑深部灰质核团或脑干、小脑病变8例。结论MELAS综合征MRI表现具有一定特征性,MRI检查对MELAS综合征的诊断具有重要提示价值,结合肌肉活检可明确该病的诊断。Objective To study the MRI features of MELAS syndrome. Methods Clinical and MR imaging data were retrospectively analyzed of eleven patients with pathologically proved MELAS. Results MRI in all patients showed multifocal stroke-like lesions which indicated middle or low signals on T1WI and high signals on T2 WI. The lesions located within the cerebral cortical and sub-cortical region of the occipital （9 cases）, parietal （7 cases）, temporal （6 cases） and frontal lobe （2 cases）, and acrossed vascular boundaries. No main artery stenosis seen on MRA images. Basal ganglia involvement was found in 7 patients. Conclusion There are some MRI features in MELAS syndrome. MRI examination has important value in the diagnosis of MELAS. It could be definitely diagnosed by MRI combined muscle biopsy findings.

关 键 词：线粒体脑肌病 线粒体脑肌病伴高乳酸血症及卒中样发作 磁共振成像 

分 类 号：R747.9[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]