炎性细胞因子水平和急性脑梗死恶化相关研究  

Correlative study on inflammatory cytokine levels and neurological worsening in acute cerebral infarction

作　　者：黄焕章[1] 周丹[1] 李洪[1] 凌紫云[1] 

机构地区：[1]广东江门市中心医院神经内科,江门529100

出　　处：《中国实用神经疾病杂志》2009年第14期3-5,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨白介素-6水平与脑梗死早期神经症状恶化的关系。方法206位首发脑梗死发病24h内入院病人为研究对象。脑卒中患者临床神经功能缺损程度评分在入院后48h内上升至少1分定义为神经症状恶化。入院后检测206例病人血浆白介素-6水平,其中98例病人同时取样检测脑脊液白介素-6水平。结果66例(32%)病人在48h内恶化。血浆白细胞介素或脑脊液白细胞介素是早期临床恶化独立因素。血浆白细胞介素-6水平与病人体温、血糖、纤维蛋白原和脑梗死体积高度相关。结论白细胞介素-6除了参与局部脑缺血后急性期反应外,其水平还与早期临床恶化相关。白细胞介素-6水平检测可作为急性脑缺血预后指标。Objective To assess the implication of interleukin-6 （IL-6） in early neurological worsening in cerebral infarction. Methods Two hundred and six patients consecutively admitted with first-ever ischemic cerebral infarction within the first 24 hours from onset were selected. Neurological worsening was defined when the Chinese Stroke Scale （CSS） score added at least 1 point during the first 48 hours after admission. IL-6 was determined in plasma and cerebrospinal fluid （n=98） obtained on admission. Results Sixty-six patients （32%） deteriorated within the first 48 hours. IL-6 in plasma or CSF were independent factors of early clinical worsening. IL-6 in plasma was highly correlated with body temperature, glucose, fibrinogen, and infarct volume. Conclusion In addition to participating in the acute-phase response that follows focal cerebral ischemia, IL-6 levels on admission are associated with early clinical deterioration. The measure of level of IL-6 can be taken as index of progno- sis of acute cerebral infarction.

关 键 词：白细胞介素-6 脑梗死 神经症状恶化 

分 类 号：R743.33[医药卫生—神经病学与精神病学]