复发性口腔溃疡儿童的T细胞亚群及微量元素的研究  

Study of T cells subpopulation and trace elements in children with recurrent oral ulcer

作　　者：黄晓佳[1] 何晓雷[1] 吴志芳[1] 苏吉梅[1] 阮文华[1] 

机构地区：[1]浙江大学医学院附属儿童医院口腔科,浙江杭州310003

出　　处：《全科医学临床与教育》2009年第4期359-360,363,共3页Clinical Education of General Practice

摘　　要：目的研究复发性口腔溃疡(ROU)儿童的T细胞亚群和微量元素在血清中的变化。方法临床随机抽取2～12岁患ROU的儿童及年龄性别相当的健康儿童各25例,采静脉血,用多色流式细胞仪检测T细胞亚群。用VIDE022型原子吸收分光光度仪测定血清锌、铁、铜、镁含量。结果与对照组比较,ROU组T细胞亚群(CD3、CD4、CD4/CD8)水平均降低,差异均有统计学意义(t分别=2.32、5.05、2.21,P均<0.05);ROU组微量元素中的锌、铁水平降低,差异均有统计学意义(t分别=4.27、3.95,P均<0.05),而两组的镁和铜比较,差异均无统计学意义(t分别=0.25、1.93,P均>0.05)。结论T细胞亚群、锌和铁降低可能与儿童复发口腔溃疡的发生有关。Objective To study the blood serum diversification of T cells subpopulation, and trace elements in children suffered from recurrent oral ulcer （ROU）. Method Twenty five children with ROU （aged 2-12 years old） and 25 health children （aged 2-12 years old） were involved in the study. T cells subpopulations were tested by haemospasia and flow cytometry. The content of trace elements in serum was treated by atomic absorption spectraluminosity rite. Results The levels of CD3, CD4, CD4/CD8 and the contents of Zn and Fe in the children with ROU were lower than those in the health children, the statistic difference were remarkable （t=2.32, 5.05, 2.21, 4.27, 3.95, P〈0.05）. The contents of Mg and Cu had no statistic difference between the two groups （t=0.25,1.93,P〉0.05）. Conclusions The decrease of T cells subpopulation and the contents Zn and Fe may be related to the occurrence of ROU in children.

关 键 词：复发性口腔溃疡 T细胞亚群 微量元素 

分 类 号：R781.5[医药卫生—口腔医学] R512.62[医药卫生—临床医学]