正常视网膜血管直径的非对称性研究  

Non-symmetry in the calibre of retinal blood vessels

作　　者：高磊[1] 王富华[1] 陈宁[1] 东长霞[1] 刘淑君[1] 

机构地区：[1]青岛大学医学院附属烟台毓璜顶医院眼科,中国山东省烟台市264000

出　　处：《国际眼科杂志》2009年第8期1537-1539,共3页International Eye Science

摘　　要：目的:利用IMAGEnet软件对眼底血管造影数字图像进行视网膜血管直径测量以探讨正常眼视网膜血管直径是否存在差异。方法:利用IMAGEnet软件对眼底血管造影数字图像进行放大和对比度调整,测量4个象限近视盘周围1PD范围内的视网膜动脉直径(RAD)和静脉直径(RVD),计算视网膜动静脉比值(A/V)并检验该测量方法的可重复性。结果:左右眼对应象限之间的RAD,RVD和A/V比值差异无统计学意义,但对单眼而言,颞侧与鼻侧象限的RAD和RVD以及A/V比值有着显著性差异。可重复性检验以类内相关系数(intraclass correlation coefficient,ICC)来表示,RAD的者内信度为0.97(P<0.01),RVD为0.986(P<0.01);RAD的者间信度为0.976(P<0.01),RVD为0.975(P<0.01)。结论:正常双眼对应象限的视网膜血管直径没有差异,但单眼不同象限的视网膜血管直径存在差异,利用IMAGEnet软件对视网膜荧光造影血管直径进行测量是可行和可靠的。AIM： To investigate whether there is difference in the calibre of retinal blood vessels in digital image of fluorescein angiography by IMAGEnet software. METHODS： Digital color and fluorescein angiograms were amplified and adjusted using IMAGEnet software. The retinal vascular caliber close to optic disc in four quadrants （ within 1 PD the optic disc） was measured using linear measuring tools provided by the software, and the ratio of retinal arteriolar-to-venular diameter was calculated. The within-operator and between-operator reliability of this method was investigated with intraclass correlation coefficient （ICC）. RESULTS： There was no significant difference between right eye and left eye for vascular diameter in corresponding quadrants of both eyes. However, significant difference was found between temporal and nasal quadrant for most of items in one eye. The withinoperator ICCs of retinal arteriolar and venular diameter were 0.97 and 0. 986 respectively. The between-operator ICCs of retinal arteriolar and venular diameter were 0.976 and 0. 975 respectively. CONCLUSION： There is no significant difference in the diameter of retinal blood vessel between the corresponding normal quadrants of both eyes, but significant difference exists between different quadrants of one eye. It is feasible and dependable to measure the calibre of digital image of retinal blood vessels with IMAGEnet.

关 键 词：视网膜血管直径 计算机图像分析 眼底荧光血管 造影 

分 类 号：R774.1[医药卫生—眼科]