立宝舒卡波姆眼用凝胶治疗干眼的临床观察  

Clinical study of Liposic in treating dry eye patients

作　　者：邓志宏 赵少贞[1] 张未娟[1] 赵小云[1] 

机构地区：[1]天津医科大学眼科中心,中国天津市300070

出　　处：《国际眼科杂志》2009年第8期1540-1542,共3页International Eye Science

摘　　要：目的:通过观察干眼症患者使用2g/L立宝舒卡波姆眼用凝胶(简称立宝舒)前后,患者的主观症状、视力、干眼实验室检查结果以及药物的耐受性,评估立宝舒对干眼症的疗效。方法:选择干眼症患者100例200眼,予以2g/L立宝舒卡波姆眼用凝胶滴双眼,4次/d。观察就诊当天、用药7,14,28d后患者主观症状:干燥感、异物感、酸痛感、眼疲劳、眼红、畏光;视力、干眼实验室检查:泪膜破裂时间(break-uptime,BUT)、荧光素染色、SchirmerⅠ试验、SchirmerⅡ试验、睑板腺功能检查结果以及患者用药的耐受性。结果:用药7d后,患者的干燥感、异物感、酸痛感、眼疲劳、眼红、畏光等主观症状的分级与用药前有显著差异(P<0.01),随着用药时间的延长,6种主观症状明显缓解;但患者不同时间的视力无明显差异(P>0.05)。用药后患者的BUT及SchirmerⅠ,SchirmerⅡ值与用药前有显著差异(P<0.01),并且随着用药时间的延长,患者BUT及SchirmerⅠ,SchirmerⅡ值明显延长;但不同时间的睑板腺功能分级无明显差异(P>0.05);用药后患者荧光素染色分级及泪膜脂质干涉Yakoi分级与用药前有显著差异(P<0.01)。所有观察病例中未发现明显不耐受药物的患者。结论:2g/L的立宝舒卡波姆眼用凝胶可以明显改善干眼患者的眼部症状和干眼实验室检查结果,药物耐受性好,但对患者视力和睑板腺功能无明显改善作用。AIM： To investigate the effect of Liposic on dry eye, we survey the subjective symptoms, visual acuity , and results of laboratory examination in dry eye patients before and after treated with Liposic. METHODS, One hundred dry eye patients（200 eyes） were treated Liposic, four times a day. The subjective symptoms, laboratory examination of dry eye and tolerance of patients were observed on the visit day, 7, 14, 28 days after treated with Liposic. The subjective symptoms included the dry sensation, foreign body sensation, aching pain, asthenopia and photophobia , and the laboratory examination of dry eye included BUT test, Schirmer Ⅰ test（S It） , Schirmer Ⅱ test（SⅡ t）, fluorescein staining, and examination in the function of melbomian gland. RESULTS. After treated with Liposic for 7 days, the subjective symptoms of dry eye patients were relieved compared with untreated patients （P 〈 0. 01 ）, but no significant difference could be observed in the visual acuity between treated and untreated patients （ P〉 0.05）. The results of BUT, S Ⅰ t and SⅡ t, fluorescein staining and Yakoi grade were also improved after treated with Liposic（ P 〈 0.01 ） . But but no significant difference could be observed in the function test of melbomian gland between treated and untreated patients （ P 〉 0.05）. All patients showed good tolerance to Liposic. CONCLUSION. The subjective symptoms and results of laboratory examination in dry eye patients were improved after treated Liposic, but Liposic could not affect the visual acuity and the function of melbomian gland , and liposic was tolerated to the dry eye patients.

关 键 词：干眼 立宝舒 人工泪液 

分 类 号：R777[医药卫生—眼科]