肠道菌群失调对小鼠IL-3、GM-CSF水平的影响  

Influence of intestinal dysbacteriosis on mice′s IL-3、GM-CSF level

作　　者：张亚超[1] 孙晓利[1] 刘颖[1] 刘惠敏[1] 王憬[1] 王沛[1] 

机构地区：[1]白求恩军医学院仪器中心,石家庄市050081

出　　处：《临床合理用药杂志》2009年第17期5-6,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察肠道菌群失调小鼠体内白细胞介素-3(IL-3),粒-巨噬细胞集落刺激因子(GM-CSF)水平的变化。方法采用抗生素脱污染造成小鼠肠道菌群失调的动物模型,实验组和对照组各10只;用ELISA方法检测血清IL-3和GM-CSF含量。结果实验组小鼠血清中IL-3和GM-CSF的含量明显低于对照组,差异有统计学意义(P<0.01)。结论肠道菌群失调可减少体内IL-3和GM-CSF含量。Objective To study the influence of dysbaeteriosis on miee＇s IL-3 ,GM-CSF level. Methods Dysbaeteriosis caused by antibiotie decontamination of animal models were randomly divided into experimental group and control group ; Test the content of IL-3 and GM-CSF by ELISA. Results Content of IL-3 , GM-CSF have obviously decreased when compared with that in the control group, the differences were signifieantly （P〈0.01）. Conclusion The results suggest that intestinal dyshaeteriosis have obvious influence on the eontent of IL-3 and GM-CSF of miee＇s.

关 键 词：菌群失调 IL-3 GM-CSF 小鼠 

分 类 号：R574[医药卫生—消化系统]