负荷量伊班膦酸钠治疗恶性肿瘤转移性骨痛的疗效和安全性分析  

Efficiency and Safety Analysis of Loading Dose of Ibandronate for Metastatic Bone Pain Induced by Malignant Tumor

作　　者：刘晓梅[1] 张银旭[1] 朱志图[1] 哈敏文[1] 王政华[1] 

机构地区：[1]辽宁医学院附属第一医院肿瘤科,辽宁锦州121000

出　　处：《肿瘤防治研究》2009年第8期693-695,共3页Cancer Research on Prevention and Treatment

摘　　要：目的探讨首剂负荷量伊班膦酸钠(Ibandronate)治疗恶性肿瘤转移性骨痛的疗效和安全性。方法回顾性分析2007年10月～2008年4月本院收治的18例接受负荷量伊班膦酸钠治疗恶性肿瘤骨转移的患者,伊班膦酸钠4mg溶于500ml生理盐水中静滴,持续4天(总共16mg)强化治疗,观察并记录止痛起效时间、疼痛评分、KPS评分、吗啡日消耗量、血钙、肌酐等变化。结果治疗后13例疼痛缓解,缓解率72.2%,疼痛缓解平均所需时间(3.7±0.8)天,治疗后疼痛评分显著改善,生活质量评分显著提高(P<0.05),其中有4例治疗后吗啡用量减少20～60mg。不良反应少,未出现肾脏毒性反应。结论伊班膦酸钠负荷量给药止痛起效快,不良反应轻,可明显改善转移性骨痛,提高患者的生活质量,减少吗啡用量,避免吗啡不良反应的发生,并能有效降低血钙,是恶性肿瘤转移性骨痛治疗的一个新选择。Objective To evaluate the efficiency and safety of loading dose of Ibandronate in the treatment of metastatic bone pain （MBP） induced by malignant tumors. Methods Eighteen patients with malignant tumor who were to be in our hospital and treated with Ibandrnate were analyzed retrospectively. Ibandronate was administered intravenously 4 mg per day at loading dose in more than 30 min for 4 consecutive days. Onset time, pain score, KPS score and daily morphine consumption were recorded. The serum markers such as calcium, creatinine were monitored. Results Eighteen cases were eligible to evaluate the efficiency and safety. Among them, the pain of 13 cases （72. 20%） was relieved. The average onset time was （3. 7 ± 0. 8）days. The pain score was significantly decreased after treatment and the life quality of patients was markedly improved （P〈0. 05）. The morphine consumption was reduced by about 20 mg to 60 mg in 4 cases after treatment. The adverse reaction was relieved and no renal toxicity was observed. Conclusion Administration of loading dose of Ibandronate had quick onset time and mild side effects. It could significantly relieve metastasis bone pain and improve KPS, reduce the morphine consumption dose, avoid morphine-induced side effect, and effectively decrease serum calcium level.

关 键 词：恶性肿瘤 转移 骨痛 伊班膦酸钠 

分 类 号：R730.6[医药卫生—肿瘤]