番茄红素对血液透析患者静脉铁剂诱导微炎症状态的影响  

Effects of Lycopene on Inflammation Induced by Intravenous Iron in Maintenance Hemodialysis Patients

作　　者：金领微[1] 郑育[1] 叶菡洋[1] 周志宏[1] 李占园[1] 陈辉乐[1] 毛朝鸣[1] 戴彩香[1] 杨筱敏[1] 

机构地区：[1]温州医学院附属第二医院肾内科,温州325088

出　　处：《中国中西医结合肾病杂志》2009年第8期705-708,共4页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：温州市科技局基金资助项目(No.Y2008046)

摘　　要：目的:观察维持性血液透析(MHD)患者由静脉铁剂诱导的微炎症状态,探讨番茄红素对其的干预作用。方法:60例MHD患者,随机分为对照组和试验组,每组各30例。对照组:在患者透析时给予蔗糖铁注射液100mg,2次/周,共10次,观察时间8周。试验组:除蔗糖铁注射液使用外,同时口服番茄红素胶囊,2粒/次,2次/d,用药8周,观察时间8周。观察并比较两组患者治疗前及治疗8周后的血红蛋白(Hb)、红细胞比容(Hct)、血清铁(SI)、铁蛋白(SF)、转铁蛋白饱和度(TSAT)以及白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)等指标的变化。结果:两组患者治疗后IL-1β、IL-6、TNF-α及CRP水平较治疗前均有显著性升高(P<0.01或P<0.05),但是试验组升高幅度显著性小于对照组(P<0.01);试验组患者治疗后IL-10水平较治疗前有显著性升高(P<0.01),并且试验组升高幅度显著性大于对照组(P<0.05);两组血清IL-6、TNF-α水平均与SF呈正相关(P<0.01);两组Hb、Hct、SI、SF、TSAT较治疗前均有显著性升高(P<0.01),并且两组升高幅度相似,差异无统计学意义。结论:静脉铁剂治疗加剧了MHD患者的微炎症状态。番茄红素可减轻这种微炎症状态。Objective：To observe inflammation induced by intravenous iron and its prevention by lycopene in maintenance hemodialysis（MHD） patients. Methods： 60 MHD patients were randomly divided into two groups： control group（ n = 30） and treatment group（ n = 30）. In control group, the patients were treated with iron sucrose, 100 mg intravenous, during 10 consecutive hernodialysis sessions,twice a week for five weeks. In treatment group, in addition to intravenous iron, the patients were given lycopene, 2# oral, twice a day for eight weeks. Their hemoglobin （Hb）, hematocrit （Hct）, serum iron（SI）, serum ferritin（SF）, transferring saturation （TAST）, IL - 1β, IL - 6, IL - 10,TNF - α and CRP were measured at pre- and post - treatment. Results：Compared with the pre- treatment, the levels of serum IL- 1β, IL- 6, TNF- a and CRP in both groups elevated markedly（ P 〈 0.01 or P〈0.05）. But the increase rate of serum L- 1β, 1L- 6,TNF- α and CRP in treatment group was less than those in control group （P〈 0.01 ）. Compared with the pre- treatment, the levels of serum IL- 10 in treatment groups were elevated significantly （P 〈 0.01 ）. Moreover, the increase rate of IL - 10 in treatment group was more than that in control group （P〈O. 05）. At post - treatment, the levels of serum IL - 6 and TNF -α were positively correlated to the levels of SF in both group （ P 〈 0.01 ）. Compared with the pre - treatment, the levels of Hb, Hct, SI, SF, and TSAT increased significantly in both groups （ P 〈 0.01 ） at post - treatment. Moreover, the increase rates of them were no significantly different between both of groups. Conclusion： Intravenous iron therapy could induce aggravation of the inflammation in MHD patients, which could be alleviated by lycopene.

关 键 词：番茄红素 炎症 静脉铁剂 血液透析 

分 类 号：R459.5[医药卫生—治疗学] R151.3[医药卫生—临床医学]