75MeV/u￣(12)C离子Bragg曲线及黑色素瘤细胞失活的测量  

Measurements of Bragg curve for 75MeV/u 12C ion beam and its inactivation effect on melanoma cells

作　　者：李强[1] 卫增泉 李文建[1] 周光明[1] 党秉荣[1] 蔡喜臣[1] 何静[1] 颉红梅[1] 韩光武[1] 黄涛 陈卫强[1] 王菊芳[1] 张树民[1] 

机构地区：[1]中国科学院近代物理研究所

出　　处：《核技术》1998年第8期470-473,共4页Nuclear Techniques

基　　金：国家科委攀登计划(B)项目

摘　　要：用双电离室法测定了ＨＩＲＦＬ提供的７５ＭｅＶ／ｕ１２Ｃ离子经不同厚度降能片后的相对剂量，将降能片厚度等效为组织等效材料一水中的深度，得到了碳离子在水介质中的Ｂｒａｇｇ曲线，与计算的Ｂｒａｇｇ曲线进行了比较。同时测定了离子经不同厚度降能片后对黑色素瘤（Ｂ１６）细胞的失活效应，得到了离子束在不同贯穿深度上的Ｂ１６细胞存活数据。Relative doses of 75MeV/u 12C ion beam after passing through different thickness of degraders were measured with the double ionization chamber method. The degrader's thickness as then equalized to penetration depth of the beam in water and its Bragg curve was obtained. The measured Bragg curve is compared with that calculated based on a model set up by the authors. Meanwhile, the inactivation effect of the ion beam passing through different thickness of degraders on melanoma (B16)cells was measured, and the corresponding survival fraction data for B16 cells were acquired.

关 键 词：离子束 Bragg曲线 黑色素瘤细胞 失活 碳12 

分 类 号：R730.55[医药卫生—肿瘤] R817.5[医药卫生—临床医学]