肺癌血管内皮生长因子的表达及其意义  

EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) IN LUNG CARCINOMAS AND ITS SIGNIFICANCE

作　　者：姜彦多[1] 夏书月 王继红[1] 何安光[1] 王晓牧[1] 

机构地区：[1]解放军第202医院

出　　处：《解放军医学杂志》1998年第3期178-180,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：采用ＳＰ免疫组织化学方法观察血管内皮生长因子（ＶＥＧＦ）在９４例肺癌组织的表达。结果显示，ＶＥＧＦ在肺癌组织表达的阳性率为７０．２％，明显高于癌旁正常组织。鳞癌和腺癌ＶＥＧＦ阳性组，其微血管计数值和增殖细胞栓抗原（ＰＣＮＡ）标记指数均高于阴性组。腺癌ＶＥＧＦ的表达与转移、分期和病理学分级等因素均无关；在鳞癌，有淋巴结转移组ＶＥＧＦ的阳性率高于无淋巴结转移组，Ⅲ～Ⅳ期癌高于Ⅰ～Ⅱ期癌。结果提示，ＶＥＧＦ表达与肺癌的发生有关，并能促进肺癌血管形成，使癌细胞的增殖活性升高。ＶＥＧＦ表达与肺鳞癌淋巴结转移和进展有关。To examine the expression of VEGF and to determine whether the expression of VEGF correlates with vascularization, metastasis, and proliferation in lung carcinomas. The expression of VEGF was observed immunohistochemically on formalin fixed, paraffin embedded sections. The VEGF positive rate was significantly higher in carcinoma tissues than in normal tissues adjacent to carcinomas. The microvessel count and PCNA labelling index in VEGF positive tumors were significantly higher than those in VEGF negative tumors. No relationship was found between VEGF expression and clinicopathological parameters including tumor grade, nodal involvement and stage in adenocarcinomas. In squamous carcinomas, there was a significant increase in VEGF positive rate in tumors with lymph nodal metastases and of advanced stages. The expression of VEGF correlated with carcinogenesis, vascularization, proliferation, metastasis and progression, and might be a good prognostic indicator for patients with lung carcinomas.

关 键 词：肺肿瘤 内皮生长因子 免疫组化 

分 类 号：R734.202[医药卫生—肿瘤]