胃癌中生长抑素表达的临床病理意义及DNA含量分析  

CLINICOPATHOLOGIC SIGNIFICANCE OF GENE EXPRESSION AND DNA CONTENT ANALYSIS OF SOMATOSTATIN IN GASTRIC CARCINOMA

作　　者：王鲁平[1] 虞积耀[1] 丁华野[1] 吴霞[1] 田玉旺[1] 邓永江[1] 邢惠清[1] 

机构地区：[1]北京军区总医院

出　　处：《解放军医学杂志》1998年第3期175-177,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：应用免疫组化及图像分析技术观察１４０例各组织学类型胃癌中生长抑素（ＳＳ）的表达，并随访其中１２７例。３６例胃癌中检出ＳＳ阳性细胞（２５．７％）。ＳＳ的表达与胃癌组织学类型、分化及淋巴结转移无明显关系，但与预后有明显关系。ＳＳ阳性胃癌组预后较好，较ＳＳ阴性胃癌组生存期长（Ｐ＜０．０１）。ＤＮＡ图像分析结果显示，与ＳＳ阴性胃癌组相比，ＳＳ阳性胃癌组的３～４Ｃ细胞与５Ｃ细胞所占比例较大，＞５Ｃ细胞所占比例较小。上述结果提示ＳＳ作为抑制因子不仅可抑制胃癌细胞的生长，而且含有ＳＳ细胞的胃癌患者生存期长，预后较好。推测胃癌中分泌的ＳＳ和其自身膜表达受体结合，抑制自身生长。胃癌中ＳＳ与ＳＳ受体相互间的关系及对胃癌的影响尚须进一步研究。Expressions of somatostatin(SS) in 140 cases of gastric carcinoma(GC) were observed by immunohistochemistry and DNA analysis. Of them, 127 cases were followed up. SS positive gastric carcinoma was demonstrated in 36 cases (25 7%). Expression of SS in GC was not related to histological types, differentiation and metastasis of lymphnodes, and was related to prognosis. The patients of SS postive GC survived longer than SS negative GC( P <0 01). DNA analysis showed that there were more 3 4C,5C cells and less>5C cells in SS positive GC group than in SS negative GC group. The results suggested that SS not only could inhibit growth of GC cells, but had better prognosis in patients with SS positive GC cells.

关 键 词：胃肿瘤 生长抑素 基因表达 临床病理 DNA 

分 类 号：R735.202[医药卫生—肿瘤]