p16蛋白在大肠癌中的表达及其临床意义  

p16 Protein Expression and its Clinical Significance inHuman Colorectal Carcinoma

作　　者：李玉军[1] 纪祥瑞[1] 姜天福[1] 赵洁[1] 

机构地区：[1]青岛医学院附属医院病理科

出　　处：《实用癌症杂志》1998年第3期174-175,共2页The Practical Journal of Cancer

摘　　要：应用免疫组化ＬＳＡＢ法检测了１０５例大肠癌组织中ｐ１６蛋白。结果：大肠癌ｐ１６蛋白表达阳性率为６０．０％，与癌组织分化程度呈正相关（Ｐ＜０．０１），与癌组织浸润深度和Ｄｕｋｅｓ′分期呈负相关（Ｐ＜０．０１）。无区域淋巴结转移者的ｐ１６蛋白表达阳性率为７６．９％，伴区域淋巴结或远处器官转移者为５０．０％，二者有显著性差异（Ｐ＜０．０１）。生存超过５年者ｐ１６蛋白表达阳性率（８３．３％）明显高于５年内死亡者（５３．１％），有显著性差异（Ｐ＜０．０５）。说明ｐ１６基因能抑制大肠癌的浸润与转移。The expression of p16 protein was examined immunohistochemically in 105 cases of resected human colorectal carcinomas.The results showed that there was 60.0%(63 cases) positive staining of p16 protein in the primary lesions.Inverse relation was found between p16 protein expression and tumor invasion or progression of Dudes′s stage(P<0.01).The positive staining rate in patients without regional lymph node metastasis was significantly higher than that in those with nodal or organ involvement(P<0.01).Expression of p16 protein was positively associated with longer postoperative survival (5 years) (P<0.05).These results suggest that p16 gene play an important role in lymph node metastasis and invasion in colorectal carcinoma and may serve as an indictor to predict the prognosis of patients.

关 键 词：大肠肿瘤 P16蛋白 基因表达 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]